en
Scientific article
Open access
English

Model systems for regeneration: Hydra

Published inDevelopment, vol. 146, no. 21
Publication date2019
Abstract

The freshwater polyp Hydra provides a potent model system for investigating the conditions that promote wound healing, reactivation of a developmental process and, ultimately, regeneration of an amputated body part. Hydra polyps can also be dissociated to the single cell level and can regenerate a complete body axis from aggregates, behaving as natural organoids. In recent years, the ability to exploit Hydra has been expanded with the advent of new live-imaging approaches, genetic manipulations that include stable transgenesis, gene silencing and genome editing, and the accumulation of high-throughput omics data. In this Primer, we provide an overview of Hydra as a model system for studying regeneration, highlighting recent results that question the classical self-enhancement and long-range inhibition model supposed to drive Hydra regeneration. We underscore the need for integrative explanations incorporating biochemical as well as mechanical signalling.

Keywords
  • Hydra model system
  • Genetic manipulation
  • Organizer centre
  • Organoid
  • Reaggregation
  • Regeneration
Funding
  • Swiss National Science Foundation - 31003_169930, 310030_189122
Citation (ISO format)
VOGG, Matthias Christian, GALLIOT, Brigitte, TSIAIRIS, Charisios D. Model systems for regeneration: Hydra. In: Development, 2019, vol. 146, n° 21. doi: 10.1242/dev.177212
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0950-1991
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