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Circadian Rhythms in Drosophila: From the Core Clock to Complex Behaviors

Defense Thèse de doctorat : Univ. Genève, 2019 - Sc. 5394 - 2019/10/01
Abstract If nuclear receptors are key components of the mammalian molecular clock, their role in the Drosophila circadian rhythms remained poorly understood. In this thesis, I first focused on the nuclear receptor E75, which appeared to be a crucial modulator for the fly molecular clock. I then focused on a non-circadian neuronal structure of the Drosophila's brain called the Mushroom Body. Despite not expressing the molecular clock itself, this center modulates numerous complex circadian behaviors. Circadian RNA-seq analysis of this structure revealed key genes involved in sleep regulation.
Keywords DrosophilaCircadianMushroom bodyTranscriptomerna-seqE75EcdysoneUNFNF1Neurofibromin-1pka-c1
URN: urn:nbn:ch:unige-1255130
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Research group Groupe Nagoshi
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MACHADO ALMEIDA, Pedro. Circadian Rhythms in Drosophila: From the Core Clock to Complex Behaviors. Université de Genève. Thèse, 2019. doi: 10.13097/archive-ouverte/unige:125513 https://archive-ouverte.unige.ch/unige:125513

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Deposited on : 2019-10-31

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