en
Doctoral thesis
English

Circadian Rhythms in Drosophila: From the Core Clock to Complex Behaviors

DirectorsNagoshi, Emiorcid
Defense date2019-10-01
Abstract

If nuclear receptors are key components of the mammalian molecular clock, their role in the Drosophila circadian rhythms remained poorly understood. In this thesis, I first focused on the nuclear receptor E75, which appeared to be a crucial modulator for the fly molecular clock. I then focused on a non-circadian neuronal structure of the Drosophila's brain called the Mushroom Body. Despite not expressing the molecular clock itself, this center modulates numerous complex circadian behaviors. Circadian RNA-seq analysis of this structure revealed key genes involved in sleep regulation.

eng
Keywords
  • Drosophila
  • Circadian
  • Mushroom body
  • Transcriptome
  • rna-seq
  • E75
  • Ecdysone
  • UNF
  • NF1
  • Neurofibromin-1
  • pka-c1
Research group
Citation (ISO format)
MACHADO ALMEIDA, Pedro. Circadian Rhythms in Drosophila: From the Core Clock to Complex Behaviors. 2019. doi: 10.13097/archive-ouverte/unige:125513
Main files (1)
Thesis
accessLevelRestricted
Identifiers
317views
2downloads

Technical informations

Creation10/17/2019 11:56:00 PM
First validation10/17/2019 11:56:00 PM
Update time03/15/2023 6:17:27 PM
Status update03/15/2023 6:17:26 PM
Last indexation01/29/2024 10:02:38 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack