en
Scientific article
Open access
English

Feeling of presence in dementia with Lewy bodies is related to reduced left frontoparietal metabolism

Published inBrain Imaging and Behavior, vol. 14, no. 4, p. 1199-1207
Publication date2020
Abstract

Feeling of presence (FOP) refers to the vivid sensation of a person's presence near oneself and is common in Dementia with Lewy Bodies (DLB). Based on previous observations on epileptic subjects, we hypothesized that DLB subjects with FOP would harbour 18F-fluorodeoxyglucose PET hypometabolism in left parietal areas. 25 subjects (mean age 71.9 ± 6.7, disease duration at scan 1.7 ± 1.5 years) were included in the study, of whom nine (36%) experienced FOP. No significant between-group difference was observed regarding dopamine transporters striatal uptake (p = 0.64), daily dopaminergic treatment dosage (p = 0.88) and visual hallucinations (p = 0.83). Statistical parametric mapping showed that subjects with FOP had a significantly reduced glucose metabolism in several left frontoparietal areas (p < 0.001), including superior parietal lobule and precuneus. Interregional correlation analysis of these areas showed specific connectivity with right insula and putamen in the FOP subgroup and right orbitofrontal and superior frontal in subjects without FOP. This provides further evidence about the role of a left frontoparietal network and suggest a possible contribution of impaired orbitofrontal reality filtering associated with FOP.

Keywords
  • Psychosis Dementia
  • Brain glucose metabolism
  • Statistical parametric mapping
Citation (ISO format)
NICASTRO, Nicolas et al. Feeling of presence in dementia with Lewy bodies is related to reduced left frontoparietal metabolism. In: Brain Imaging and Behavior, 2020, vol. 14, n° 4, p. 1199–1207. doi: 10.1007/s11682-018-9997-7
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1931-7557
317views
113downloads

Technical informations

Creation01/02/2019 4:24:00 PM
First validation01/02/2019 4:24:00 PM
Update time03/15/2023 6:16:36 PM
Status update03/15/2023 6:16:36 PM
Last indexation02/12/2024 11:44:08 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack