Titles listNon-inferiority of simplified dolutegravir monotherapy compared to continued combination antiretroviral...
Scientific Article
unige:125267 
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Non-inferiority of simplified dolutegravir monotherapy compared to continued combination antiretroviral therapy that was initiated during primary HIV infection: a randomized, controlled, multi-site, open-label, non-inferiority trial |
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| Published in | Clinical Infectious Diseases. 2019, vol. 69, no. 9, p. 1489-1497 | |
| Abstract | Patients who start combination antiretroviral therapy (cART) during primary HIV-1 infection show a smaller HIV-1 latent reservoir, less immune activation and a smaller viral diversity compared to patients who start cART during chronic infection. We conducted a pilot study to test whether these properties would allow sustained virological suppression after simplification of cART to dolutegravir monotherapy. | |
| Keywords | Primary HIV infection — Dolutegravir — Monotherapy — Simplification — Randomized controlled trial | |
| Identifiers | DOI: 10.1093/cid/ciy1131 PMID: 30601950 | |
| Full text |
 Article (Accepted version) (2.6 MB) -  Free access Article (Published version) (3.2 MB) -  Limited access to UNIGEOther version: https://academic.oup.com/cid/article/69/9/1489/5269466 Dataset: https://academic.oup.com/cid/article/69/9/1489/5269466#supplementary-data |
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| Research group | Maladies infectieuses et modèles mathématiques (988) | |
| Projects | FNS: 179571 FNS: PZ00P3-142411 FNS: BSSGI0_155851 FNS: 324730-165956 | |
| Citation (ISO format) | BRAUN, Dominique L et al. Non-inferiority of simplified dolutegravir monotherapy compared to continued combination antiretroviral therapy that was initiated during primary HIV infection: a randomized, controlled, multi-site, open-label, non-inferiority trial. In: Clinical Infectious Diseases, 2019, vol. 69, n° 9, p. 1489-1497. doi: 10.1093/cid/ciy1131 https://archive-ouverte.unige.ch/unige:125267 |
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