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Scientific article
Open access
English

Non-inferiority of simplified dolutegravir monotherapy compared to continued combination antiretroviral therapy that was initiated during primary HIV infection: a randomized, controlled, multi-site, open-label, non-inferiority trial

Published inClinical Infectious Diseases, vol. 69, no. 9, p. 1489-1497
Publication date2019
Abstract

Patients who start combination antiretroviral therapy (cART) during primary HIV-1 infection show a smaller HIV-1 latent reservoir, less immune activation and a smaller viral diversity compared to patients who start cART during chronic infection. We conducted a pilot study to test whether these properties would allow sustained virological suppression after simplification of cART to dolutegravir monotherapy.

Keywords
  • Primary HIV infection
  • Dolutegravir
  • Monotherapy
  • Simplification
  • Randomized controlled trial
Citation (ISO format)
BRAUN, Dominique L et al. Non-inferiority of simplified dolutegravir monotherapy compared to continued combination antiretroviral therapy that was initiated during primary HIV infection: a randomized, controlled, multi-site, open-label, non-inferiority trial. In: Clinical Infectious Diseases, 2019, vol. 69, n° 9, p. 1489–1497. doi: 10.1093/cid/ciy1131
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Identifiers
ISSN of the journal1058-4838
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Technical informations

Creation06/11/2019 11:36:00 AM
First validation06/11/2019 11:36:00 AM
Update time03/15/2023 6:16:27 PM
Status update03/15/2023 6:16:26 PM
Last indexation01/17/2024 6:40:28 AM
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