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Title

Non-inferiority of simplified dolutegravir monotherapy compared to continued combination antiretroviral therapy that was initiated during primary HIV infection: a randomized, controlled, multi-site, open-label, non-inferiority trial
Authors
Braun, Dominique L
Turk, Teja
Tschumi, Fabian
Grube, Christina
Hampel, Benjamin
Depmeier, Carsten
Schreiber, Peter W
Brugger, Silvio D
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Published in Clinical infectious diseases. 2019, vol. 69, no. 9, p. 1489-1497
Abstract Patients who start combination antiretroviral therapy (cART) during primary HIV-1 infection show a smaller HIV-1 latent reservoir, less immune activation and a smaller viral diversity compared to patients who start cART during chronic infection. We conducted a pilot study to test whether these properties would allow sustained virological suppression after simplification of cART to dolutegravir monotherapy.
Keywords Primary HIV infection — Dolutegravir — Monotherapy — Simplification — Randomized controlled trial
Identifiers
PMID: 30601950
Full text
Article (Accepted version) (2.6 MB) - public document Free access
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Other version: https://academic.oup.com/cid/article/69/9/1489/5269466
Dataset: https://academic.oup.com/cid/article/69/9/1489/5269466#supplementary-data
Structures
Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires / Institut de santé globale
Research group Maladies infectieuses et modèles mathématiques (988)
Projects
Swiss National Science Foundation: 179571
Swiss National Science Foundation: PZ00P3_142411
Swiss National Science Foundation: BSSGI0_155851
Swiss National Science Foundation: 324730_165956
Citation
(ISO format) 		BRAUN, Dominique L et al. Non-inferiority of simplified dolutegravir monotherapy compared to continued combination antiretroviral therapy that was initiated during primary HIV infection: a randomized, controlled, multi-site, open-label, non-inferiority trial. In: Clinical Infectious Diseases, 2019, vol. 69, n° 9, p. 1489-1497. doi: 10.1093/cid/ciy1131 https://archive-ouverte.unige.ch/unige:125267

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Deposited on : 2019-10-30

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