UNIGE document Scientific Article
previous document  unige:125267  next document
add to browser collection
Title

Non-inferiority of simplified dolutegravir monotherapy compared to continued combination antiretroviral therapy that was initiated during primary HIV infection: a randomized, controlled, multi-site, open-label, non-inferiority trial

Authors
Braun, Dominique L
Turk, Teja
Tschumi, Fabian
Grube, Christina
Hampel, Benjamin
Depmeier, Carsten
Schreiber, Peter W
Brugger, Silvio D
show hidden authors show all authors [1 - 21]
Published in Clinical Infectious Diseases. 2019, vol. 69, no. 9, p. 1489-1497
Abstract Patients who start combination antiretroviral therapy (cART) during primary HIV-1 infection show a smaller HIV-1 latent reservoir, less immune activation and a smaller viral diversity compared to patients who start cART during chronic infection. We conducted a pilot study to test whether these properties would allow sustained virological suppression after simplification of cART to dolutegravir monotherapy.
Keywords Primary HIV infectionDolutegravirMonotherapySimplificationRandomized controlled trial
Identifiers
PMID: 30601950
Full text
Structures
Research group Maladies infectieuses et modèles mathématiques (988)
Projects FNS: 179571
FNS: PZ00P3-142411
FNS: BSSGI0_155851
FNS: 324730-165956
Citation
(ISO format)
BRAUN, Dominique L et al. Non-inferiority of simplified dolutegravir monotherapy compared to continued combination antiretroviral therapy that was initiated during primary HIV infection: a randomized, controlled, multi-site, open-label, non-inferiority trial. In: Clinical Infectious Diseases, 2019, vol. 69, n° 9, p. 1489-1497. doi: 10.1093/cid/ciy1131 https://archive-ouverte.unige.ch/unige:125267

110 hits

39 downloads

Update

Deposited on : 2019-10-30

Export document
Format :
Citation style :