Scientific article
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English

Non-inferiority of simplified dolutegravir monotherapy compared to continued combination antiretroviral therapy that was initiated during primary HIV infection: a randomized, controlled, multi-site, open-label, non-inferiority trial

Published inClinical Infectious Diseases, vol. 69, no. 9, p. 1489-1497
Publication date2019
Abstract

Patients who start combination antiretroviral therapy (cART) during primary HIV-1 infection show a smaller HIV-1 latent reservoir, less immune activation and a smaller viral diversity compared to patients who start cART during chronic infection. We conducted a pilot study to test whether these properties would allow sustained virological suppression after simplification of cART to dolutegravir monotherapy.

Keywords
  • Primary HIV infection
  • Dolutegravir
  • Monotherapy
  • Simplification
  • Randomized controlled trial
Citation (ISO format)
BRAUN, Dominique L et al. Non-inferiority of simplified dolutegravir monotherapy compared to continued combination antiretroviral therapy that was initiated during primary HIV infection: a randomized, controlled, multi-site, open-label, non-inferiority trial. In: Clinical Infectious Diseases, 2019, vol. 69, n° 9, p. 1489–1497. doi: 10.1093/cid/ciy1131
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Article (Accepted version)
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Identifiers
Journal ISSN1058-4838
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177downloads

Technical informations

Creation11/06/2019 11:36:00
First validation11/06/2019 11:36:00
Update time20/01/2025 07:20:20
Status update20/01/2025 07:20:20
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