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Title

A Chalcogen-Bonding Cascade Switch for Planarizable Push-Pull Probes

Authors
Tajkhorshid, Emad
Published in Angewandte Chemie: International Edition. 2019, vol. 58, no. 44, p. 15752-15756
Abstract Planarizable push–pull probes have been introduced to demonstrate physical forces in biology. However, the donors and acceptors needed to polarize mechanically planarized probes are incompatible with their twisted resting state. The objective of this study was to overcome this “flipper dilemma” with chalcogen‐bonding cascade switches that turn on donors and acceptors only in response to mechanical planarization of the probe. This concept is explored by molecular dynamics simulations as well as chemical double‐mutant cycle analysis. Cascade switched flipper probes turn out to excel with chemical stability, red shifts adding up to high significance, and focused mechanosensitivity. Most important, however, is the introduction of a new, general and fundamental concept that operates with non‐trivial supramolecular chemistry, solves an important practical problem and opens a wide chemical space.
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Article (Author postprint) (2 MB) - document accessible for UNIGE members only Limited access to UNIGE (until 2020-09-25)
Other version: http://doi.wiley.com/10.1002/anie.201909741
Structures
Research group Groupe Matile
Citation
(ISO format)
MACCHIONE, Mariano et al. A Chalcogen-Bonding Cascade Switch for Planarizable Push-Pull Probes. In: Angewandte Chemie: International Edition, 2019, vol. 58, n° 44, p. 15752-15756. doi: 10.1002/anie.201909741 https://archive-ouverte.unige.ch/unige:125041

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Deposited on : 2019-10-25

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