en
Scientific article
Review
English

The molecular basis of drug addiction: linking epigenetic to synaptic and circuit mechanisms

Published inNeuron, vol. 102, no. 1, p. 48-59
Publication date2019
Abstract

Addiction is a disease in which, after a period of recreational use, a subset of individuals develops compulsive use that does not stop even in light of major negative consequences. Here, we review the evidence for underlying epigenetic remodeling in brain in two settings. First, excessive dopamine signaling during drug use may modulate gene expression, altering synaptic function and circuit activity and leading over time to maladaptive behaviors in vulnerable individuals. Second, on a longer timescale, life experience can shape the epigenetic landscape in brain and thereby may contribute to an individual's vulnerability by amplifying drug-induced changes in gene expression that drive the transition to addiction. We conclude by exploring how epigenetic mechanisms might serve as therapeutic targets for addiction treatments.

Citation (ISO format)
NESTLER, Eric J, LUSCHER, Christian. The molecular basis of drug addiction: linking epigenetic to synaptic and circuit mechanisms. In: Neuron, 2019, vol. 102, n° 1, p. 48–59. doi: 10.1016/j.neuron.2019.01.016
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0896-6273
367views
9downloads

Technical informations

Creation10/11/2019 11:16:00 AM
First validation10/11/2019 11:16:00 AM
Update time03/15/2023 6:11:12 PM
Status update03/15/2023 6:11:11 PM
Last indexation01/17/2024 6:31:16 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack