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Treatment with direct-acting antivirals improves peripheral insulin sensitivity in non-diabetic, lean chronic hepatitis c patients

ContributorsGastaldi, Giacomo Gianni Giuseppeorcid; Rocha Gomes, Diana Bianca; Schneiter, Philippe; Montet, Xavier Cédric Rodolphe; Tappy, Luc; Clement, Sophie; Negro, Francesco
Published inPLOS ONE, vol. 14, no. 6, e0217751
Publication date2019
Abstract

Hepatitis C virus (HCV) infection is associated with insulin resistance, which may lead to type 2 diabetes and its complications. Although HCV infects mainly hepatocytes, it may impair insulin sensitivity at the level of uninfected extrahepatic tissues (muscles and adipose tissue). The aim of this study was to assess whether an interferon-free, antiviral therapy may improve HCV-associated hepatic vs. peripheral insulin sensitivity.

Keywords
  • Adenine Nucleotides/pharmacology
  • Animals
  • Biological Transport/drug effects
  • Cyclic AMP/metabolism
  • Cyclooxygenase Inhibitors
  • Lymphocyte Activation
  • Lymphocytes/immunology/metabolism
  • Phytohemagglutinins/pharmacology
  • Prostaglandins E/metabolism
  • Swine
  • Uridine/metabolism
Affiliation entities
Research groups
Funding
  • Swiss National Science Foundation - 314730–166609
Citation (ISO format)
GASTALDI, Giacomo Gianni Giuseppe et al. Treatment with direct-acting antivirals improves peripheral insulin sensitivity in non-diabetic, lean chronic hepatitis c patients. In: PLOS ONE, 2019, vol. 14, n° 6, p. e0217751. doi: 10.1371/journal.pone.0217751
Main files (1)
Article (Published version)
accessLevelPublic CC BY
Identifiers
ISSN of the journal1932-6203
366views
128downloads

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Creation09/24/2019 3:41:00 PM
First validation09/24/2019 3:41:00 PM
Update time03/15/2023 6:03:45 PM
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