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Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters

Published in Chemical Communications. 2010, vol. 46, no. 39, p. 7295-7306
Abstract All-carbon quaternary stereocenters are ubiquitous motifs in biological products and pharmaceutical agents. However, due to sterical reasons, these centers are not always easily accessible. The metal-catalyzed conjugate addition reaction to trisubstituted conjugated substrates presents a viable methodology to create quaternary centers. In this article, different ways of activating the conjugate system towards nucleophilic addition will be described. An overview will be given on the different types of quaternary centers that are accessible through the conjugate addition reaction.
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HAWNER, Christine, ALEXAKIS, Alexandre. Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters. In: Chemical Communications, 2010, vol. 46, n° 39, p. 7295-7306. doi: 10.1039/c0cc02309d https://archive-ouverte.unige.ch/unige:12131

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Deposited on : 2010-10-18

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