Scientific article

Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters

Published inChemical communications, vol. 46, no. 39, p. 7295-7306
Publication date2010

All-carbon quaternary stereocenters are ubiquitous motifs in biological products and pharmaceutical agents. However, due to sterical reasons, these centers are not always easily accessible. The metal-catalyzed conjugate addition reaction to trisubstituted conjugated substrates presents a viable methodology to create quaternary centers. In this article, different ways of activating the conjugate system towards nucleophilic addition will be described. An overview will be given on the different types of quaternary centers that are accessible through the conjugate addition reaction.

Citation (ISO format)
HAWNER, Christine, ALEXAKIS, Alexandre. Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters. In: Chemical communications, 2010, vol. 46, n° 39, p. 7295–7306. doi: 10.1039/c0cc02309d
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Article (Published version)
ISSN of the journal1359-7345

Technical informations

Creation10/18/2010 9:35:00 AM
First validation10/18/2010 9:35:00 AM
Update time03/14/2023 4:07:36 PM
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