UNIGE document Scientific Article
previous document  unige:11964  next document
add to browser collection
Title

Highly Enantioselective One-Pot Copper-Catalyzed 1,4 Addition/Organocatalyzed α-Substitution of Enals

Authors
Published in Advanced Synthesis and Catalysis. 2010, vol. 352, no. 11-12, p. 1856 - 1860
Abstract The asymmetric copper-catalyzed addition of dialkylzinc to enals followed by organocatalyzed one-pot aldehyde α-functionalization has been accomplished providing CC, CCl or CF bond formation. These simple procedures led to the creation of two contiguous stereocenters in excellent enantioselectivities (typical ee=99%). This methodology has been applied in the synthesis of (2S,3S) isomer of Valnoctamide®.
Keywords CopperEnalsEnantioselectivityMichael additionOrganocatalysis
Identifiers
Full text
Article (Published version) (230 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://doi.wiley.com/10.1002/adsc.201000309
Structures
Citation
(ISO format)
QUINTARD, Adrien, ALEXAKIS, Alexandre. Highly Enantioselective One-Pot Copper-Catalyzed 1,4 Addition/Organocatalyzed α-Substitution of Enals. In: Advanced Synthesis and Catalysis, 2010, vol. 352, n° 11-12, p. 1856 - 1860. https://archive-ouverte.unige.ch/unige:11964

196 hits

3 downloads

Update

Deposited on : 2010-09-30

Export document
Format :
Citation style :