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Higher-Order Thalamocortical Inputs Gate Synaptic Long-Term Potentiation via Disinhibition

Published in Neuron. 2019, vol. 101, no. 1, p. 91-102.e4
Abstract Sensory experience and perceptual learning changes receptive field properties of cortical pyramidal neurons (PNs), largely mediated by synaptic long-term potentiation (LTP). The circuit mechanisms underlying cortical LTP remain unclear. In the mouse somatosensory cortex, LTP can be elicited in layer 2/3 PNs by rhythmic whisker stimulation. We dissected the synaptic circuitry underlying this type of plasticity in thalamocortical slices. We found that projections from higher-order, posterior medial thalamic complex (POm) are key to eliciting N-methyl-D-aspartate receptor (NMDAR)-dependent LTP of intracortical synapses. Paired activation of cortical and higher-order thalamocortical inputs increased vasoactive intestinal peptide (VIP) and parvalbumin (PV) interneuron (IN) activity and decreased somatostatin (SST) IN activity, which together disinhibited the PNs. VIP IN-mediated disinhibition was critical for inducing LTP. This study reveals a circuit motif in which higher-order thalamic inputs gate synaptic plasticity via disinhibition. This motif may allow contextual feedback to shape synaptic circuits that process first-order sensory information.
Keywords PlasticityLong-term potentiation LTPThalamusSomatosensoryBarrel cortex BCDisinhibitionPosterior medial complex of the thalamusPOmSomatostatin-expressing interneuronsSSTVasoactive-intestinal-peptide-expressing interneuronsVIPParvalbumin-expressing interneuronsPV
PMID: 30472077
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Research groups Les circuits neuronaux dans le néocortex des mammifères (855)
Organisation et plasticité des réseaux neuronaux cérébraux (148)
Projects FNS: 31003A_153448
FNS: 31003A_173125
FNS: CRSII3_154453
FNS: NCCR Synapsy 51NF40-158776
(ISO format)
WILLIAMS, Leena Eve, HOLTMAAT, Anthony. Higher-Order Thalamocortical Inputs Gate Synaptic Long-Term Potentiation via Disinhibition. In: Neuron, 2019, vol. 101, n° 1, p. 91-102.e4. https://archive-ouverte.unige.ch/unige:117726

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Deposited on : 2019-05-17

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