en
Scientific article
English

The inner lives of focal adhesions

Published inTrends in cell biology, vol. 12, no. 8, p. 382-389
Publication date2002
Abstract

In focal adhesions of eukaryotic cells, transmembrane receptors of the integrin family and a large set of adaptor proteins form the physical link between the extracellular substrate and the actin cytoskeleton. During cell migration, nascent focal adhesions within filopodia and lamellipodia make the initial exploratory contacts with the cellular environment, whereas maturing focal adhesions pull the cell forward against the resistance of 'sliding' focal adhesions at the cell rear. Experimental approaches are now available for analysing the dynamics and interior structure of these different focal adhesions. Analysing focal-adhesion dynamics using green-fluorescent-protein-linked integrin leads us to propose that the acto-myosin-controlled density and turnover of integrins in focal adhesions is used to sense the elasticity and spacing of extracellular ligands, regulating cell migration by mechanically transduced signaling.

Keywords
  • Actins/physiology
  • Animals
  • Cell Movement
  • Fluorescence Recovery After Photobleaching/methods
  • Focal Adhesions/ physiology
  • Integrin beta3/metabolism
  • Ligands
  • Membrane Glycoproteins/metabolism
  • Models, Biological
Citation (ISO format)
WEHRLE-HALLER, Bernhard, IMHOF, Beat. The inner lives of focal adhesions. In: Trends in cell biology, 2002, vol. 12, n° 8, p. 382–389.
Main files (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0962-8924
441views
0downloads

Technical informations

Creation08/27/2010 1:36:26 PM
First validation08/27/2010 1:36:26 PM
Update time03/14/2023 4:05:35 PM
Status update03/14/2023 4:05:35 PM
Last indexation02/12/2024 7:25:08 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack