Scientific article

Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice

Published inThe Journal of clinical investigation, vol. 98, no. 8, p. 1762-1772
Publication date1996

F1 hybrids of New Zealand black (NZB) and New Zealand white (NZW) mice are a model of human systemic lupus erythematosus. These mice develop a severe immune com-plex-mediated nephritis, in which antinuclear autoantibodies are believed to play the major role. We used a genetic analysis of (NZB x NZW)F1 x NZW backcross mice to provide insight into whether different autoantibodies are subject to separate genetic influences and to determine which autoantibodies are most important in the development of lupus-like nephritis. The results showed one set of loci that coordinately regulated serum levels of IgG antibodies to double-stranded DNA, single-stranded DNA, total histones, and chromatin, which overlapped with loci that were linked to the production of autoantibodies to the viral glycoprotein, gp70. Loci linked with anti-gp70 compared with antinuclear antibodies demonstrated the strongest linkage with renal disease, suggesting that autoantibodies to gp70 are the major pathogenic antibodies in this model of lupus nephritis. Interestingly, a distal chromosome 4 locus, Nba1, was linked with nephritis but not with any of the autoantibodies measured, suggesting that it contributes to renal disease at a checkpoint distal to autoantibody production.

  • Alleles
  • Animals
  • Antibodies, Antinuclear/physiology
  • Autoantibodies/ biosynthesis
  • Chromosome Mapping
  • Glycoproteins/immunology
  • Immunoglobulin G/ biosynthesis
  • Linkage (Genetics)
  • Lupus Nephritis/ genetics/immunology
  • Mice
  • Mice, Inbred NZB
  • Phenotype
Affiliation Not a UNIGE publication
Citation (ISO format)
VYSE, T. J. et al. Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice. In: The Journal of clinical investigation, 1996, vol. 98, n° 8, p. 1762–1772. doi: 10.1172/JCI118975
Updates (1)
ISSN of the journal0021-9738

Technical informations

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