UNIGE document Scientific Article
previous document  unige:116063  next document
add to browser collection
Title

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Authors
Young, Alexandra L
Marinescu, Razvan V
Oxtoby, Neil P
Bocchetta, Martina
Yong, Keir
Firth, Nicholas C
Cash, David M
Thomas, David L
show hidden authors show all authors [1 - 30]
Published in Nature Communications. 2018, vol. 9, no. 1, p. 4273
Abstract The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories. Here we introduce a machine-learning technique-Subtype and Stage Inference (SuStaIn)-able to uncover data-driven disease phenotypes with distinct temporal progression patterns, from widely available cross-sectional patient studies. Results from imaging studies in two neurodegenerative diseases reveal subgroups and their distinct trajectories of regional neurodegeneration. In genetic frontotemporal dementia, SuStaIn identifies genotypes from imaging alone, validating its ability to identify subtypes; further the technique reveals within-genotype heterogeneity. In Alzheimer's disease, SuStaIn uncovers three subtypes, uniquely characterising their temporal complexity. SuStaIn provides fine-grained patient stratification, which substantially enhances the ability to predict conversion between diagnostic categories over standard models that ignore subtype (p = 7.18 × 10-4) or temporal stage (p = 3.96 × 10-5). SuStaIn offers new promise for enabling disease subtype discovery and precision medicine.
Keywords Alzheimer Disease/genetics/pathologyFrontotemporal Dementia/genetics/pathologyGenotypeHumansModels, NeurologicalNeurodegenerative Diseases/classification/pathologyPhenotypeReproducibility of ResultsTime Factors
Identifiers
PMID: 30323170
Full text
Article (Published version) (4.9 MB) - public document Free access
Structures
Research group Troubles de mémoire et maladie d'Alzeimer (935)
Citation
(ISO format)
YOUNG, Alexandra L et al. Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference. In: Nature Communications, 2018, vol. 9, n° 1, p. 4273. https://archive-ouverte.unige.ch/unige:116063

41 hits

17 downloads

Update

Deposited on : 2019-04-10

Export document
Format :
Citation style :