The objective of this research is to determine the concentration and potential health risks of toxic metals in six most consumed freshwater fish species (Auchenoglanis occidentalis, Bagrus ubangensi, Citharinus gibbosus, Distichondus fasciolatus, Marcusenius moorii and Schilbe mystus). A total of 126 samples of these fish species were collected from seven sites of Congo River in the vicinity of Kinshasa City, Democratic Republic of the Congo. Toxic metals (Cr, Co, Ni, Zn, Se, Ag, Cd, Sn, Sb and Pb) levels in fish muscle tissues were determined using Inductively Coupled Plasma Mass Spectrometry whereas Hg analysis was carried out using atomic absorption spectrophotometry. The maximum metal concentration (mg kg-1 wet weight) of Zn (59.72), Sb (5.98) and Pb (4.96) was detected in muscle tissues of Marcusenius moorii, Citharinus gibbosus and Distichondus fasciolatus respectively. Pb, Zn, and Hg values in many fish samples exceeded the permissible levels set by Food and Agriculture Organization and World Health Organization for human consumption. Given the concentrations of Pb in all fish species and Zn in Marcusenius moorii, human health implications are likely to occur on continuous consumption. Addition, the evaluation of potential health risks for fish consumers indicates that there may or not be adverse effects.