UNIGE document Scientific Article
previous document  unige:115498  next document
add to browser collection

De novo NAD+ synthesis enhances mitochondrial function and improves health

Katsyuba, Elena
Mottis, Adrienne
Zietak, Marika
De Franco, Francesca
van der Velpen, Vera
Ryu, Dongryeol
Cialabrini, Lucia
show hidden authors show all authors [1 - 19]
Published in Nature. 2018, vol. 563, no. 7731, p. 354-359
Abstract Nicotinamide adenine dinucleotide (NAD+) is a co-substrate for several enzymes, including the sirtuin family of NAD+-dependent protein deacylases. Beneficial effects of increased NAD+ levels and sirtuin activation on mitochondrial homeostasis, organismal metabolism and lifespan have been established across species. Here we show that α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD), the enzyme that limits spontaneous cyclization of α-amino-β-carboxymuconate-ε-semialdehyde in the de novo NAD+ synthesis pathway, controls cellular NAD+ levels via an evolutionarily conserved mechanism in Caenorhabditis elegans and mouse. Genetic and pharmacological inhibition of ACMSD boosts de novo NAD+ synthesis and sirtuin 1 activity, ultimately enhancing mitochondrial function. We also characterize two potent and selective inhibitors of ACMSD. Because expression of ACMSD is largely restricted to kidney and liver, these inhibitors may have therapeutic potential for protection of these tissues from injury. In summary, we identify ACMSD as a key modulator of cellular NAD+ levels, sirtuin activity and mitochondrial homeostasis in kidney and liver.
PMID: 30356218
Full text
Article (Published version) (7.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Insuffisance rénale chronique (941)
(ISO format)
KATSYUBA, Elena et al. De novo NAD+ synthesis enhances mitochondrial function and improves health. In: Nature, 2018, vol. 563, n° 7731, p. 354-359. doi: 10.1038/s41586-018-0645-6 https://archive-ouverte.unige.ch/unige:115498

133 hits

1 download


Deposited on : 2019-03-29

Export document
Format :
Citation style :