UNIGE document Doctoral Thesis
previous document  unige:114512  next document
add to browser collection
Title

Forward genetic dissection of bacterial polarisome in Caulobacter crescentus

Author
Directors
Defense Thèse de doctorat : Univ. Genève, 2018 - Sc. 5265 - 2018/08/31
Abstract Caulobacter crescentus is a major model organism to study prokaryotic asymmetric cell division. In C. crescentus, the signal transduction pathways, localized to the opposite cell poles, dictate the cell fate by coordinating cellular differentiation and cell cycle progression. Therefore, in order to have a successful cellular proliferation, polar differentiation is highly important. Polarity is maintained by polar landmark proteins like the polar organizing protein PopZ, which plays an important role in the localization of various proteins. In this thesis, we identified two new PopZ interacting proteins, PlrA and PlrB, by exploiting the motility defect of DzitP cells (mutant of another PopZ-interacting protein) for bacterial suppressor genetics. This study showed that a simple read-out like motility can be used to dissect the members of the polarisome complexes in C. crescentus and in other bacteria.
Keywords Caulobacter crescentusCell cycleAsymmetric cell divisionCell polarityPopZZitP
Identifiers
URN: urn:nbn:ch:unige-1145122
Full text
Thesis (10.2 MB) - private document Private access (until 2020-02-11)
Structures
Citation
(ISO format)
EROGLU YUCE, Ezgi. Forward genetic dissection of bacterial polarisome in Caulobacter crescentus. Université de Genève. Thèse, 2018. https://archive-ouverte.unige.ch/unige:114512

77 hits

0 download

Update

Deposited on : 2019-02-25

Export document
Format :
Citation style :