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Title

Prostaglandin E1-Mediated Collateral Recruitment Is Delayed in a Neonatal Rat Stroke Model

Authors
Bonnin, Philippe
Pansiot, Julien
Charriaut-Marlangue, Christiane
Published in International Journal of Molecular Sciences. 2018, vol. 19, no. 10
Abstract While arterial reflow after a stroke represents an important challenge for better outcomes, it is also very important that sudden recanalization does not produce local oxidative and nitrogen species, deleterious for the brain and more particularly the immature brain. Our objective was to determine whether a supply in prostaglandin (Pg) E1 (Alprostadil), via its action on arterial pressure, might progressively improve cerebral reperfusion in a neonatal stroke model. Arterial blood flow was measured using ultrasonography. Rate-limiting and Pg terminal synthesizing enzymes were evaluated using reverse-transcriptase polymerase chain reaction. Our data suggests that a supply in PgE1 might delay and improve the ipsilateral reperfusion by decreasing thromboxane A synthase-1 gene, the density of reactive astrocytes and lesion volume.
Identifiers
PMID: 30274381
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Article (Published version) (1.3 MB) - public document Free access
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Research group Prévention des complications néonatales d'origine périnatale (990)
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BONNIN, Philippe et al. Prostaglandin E1-Mediated Collateral Recruitment Is Delayed in a Neonatal Rat Stroke Model. In: International Journal of Molecular Sciences, 2018, vol. 19, n° 10. https://archive-ouverte.unige.ch/unige:114460

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Deposited on : 2019-02-20

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