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NAB2 is a novel immune stimulator of MDA-5 that promotes a strong type I interferon response

Oberson, Anne
Barchet, Winfried
Rittner, Karola
Published in Oncotarget. 2017, vol. 9, no. 5, p. 5641-5651
Abstract Novel adjuvants are needed to increase the efficacy of vaccine formulations and immune therapies for cancer and chronic infections. In particular, adjuvants that promote a strong type I IFN response are required, since this cytokine is crucial for the development of efficient anti-tumoral and anti-viral immunity. Nucleic acid band 2 (NAB2) is a double-stranded RNA molecule isolated from yeast and identified as an agonist of the pattern-recognition receptors TLR3 and MDA-5. We compared the ability of NAB2 to activate innate immunity with that of poly(I:C), a well-characterized TLR3 and MDA-5 agonist known for the induction of type I IFN. NAB2 promoted stronger IFN-α production and induced a higher activation state of both murine and human innate immune cells compared to poly(I:C). This correlated with a stronger activation of the signalling pathway downstream of MDA-5, and IFN-α induction was dependent on MDA-5. Upon injection, NAB2 induced higher levels of serum IFN-α in mice than poly(I:C). These results suggest that NAB2 has the potential to become an efficient adjuvant for the induction of type-I IFN responses in therapeutic immunization against cancer or infections.
PMID: 29464024
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Article (Published version) (1.6 MB) - public document Free access
Research group Immunopharmacologie du cancer
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OBERSON, Anne et al. NAB2 is a novel immune stimulator of MDA-5 that promotes a strong type I interferon response. In: Oncotarget, 2017, vol. 9, n° 5, p. 5641-5651. doi: 10.18632/oncotarget.23725 https://archive-ouverte.unige.ch/unige:114099

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Deposited on : 2019-02-11

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