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Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells

Priebe, Magdalena
Widmer, Jérôme
Suhartha Löwa, Nina
Abram, Sarah-Luise
Woischnig, Anne-Kathrin
Brunetto, Priscilla S
Khanna, Nina
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Published in Nanomedicine. 2017, vol. 13, no. 1, p. 11-22
Abstract The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation of the cargo inside the hollow structure provides a physical protection from the surrounding environment. Here, silver-containing silica nanorattles (Ag@SiO2) were evaluated for their antimicrobial potential and for their impact on cells of the immune system. We show that Ag@SiO2 nanorattles exhibited a clear antibacterial effect against Escherichia coli as well as Staphylococcus aureus found in post-operative infections. Immunotoxicological analyses showed that the particles were taken up through an active phagocytic process by dendritic cells of the immune system and did not affect their viability nor induce unwanted immunological effects. Silver-containing silica nanorattles thus fulfill several prerequisites for an antibacterial coating on surgical implants.
Keywords AnimalsAnti-Bacterial Agents/pharmacologyCells, CulturedDendritic Cells/drug effects/metabolismEscherichia coli/drug effectsMetal Nanoparticles/chemistryMiceMicrobial Sensitivity TestsPhagocytosisSilicon Dioxide/chemistrySilver/pharmacologyStaphylococcus aureus/drug effects
PMID: 27545103
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Article (Accepted version) (1.4 MB) - public document Free access
Research group Immunopharmacologie du cancer
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PRIEBE, Magdalena et al. Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells. In: Nanomedicine, 2017, vol. 13, n° 1, p. 11-22. doi: 10.1016/j.nano.2016.08.002 https://archive-ouverte.unige.ch/unige:114097

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Deposited on : 2019-02-11

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