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Cortex and amygdala morphology in psychopathy

Hare, Robert D
Cavedo, Enrica
Najt, Pablo
Pievani, Michela
Rasser, Paul E
Laakso, Mikko P
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Published in Psychiatry Research. 2011, vol. 193, no. 2, p. 85-92
Abstract Psychopathy is characterized by abnormal emotional processes, but only recent neuroimaging studies have investigated its cerebral correlates. The study aim was to map local differences of cortical and amygdalar morphology. Cortical pattern matching and radial distance mapping techniques were used to analyze the magnetic resonance images of 26 violent male offenders (age: 32±8) with psychopathy diagnosed using the Psychopathy Checklist-Revised (PCL-R) and no schizophrenia spectrum disorders, and in matched controls (age: 35± sp="0.12"/>11). The cortex displayed up to 20% reduction in the orbitofrontal and midline structures (corrected p<0.001 bilaterally). Up to 30% tissue reduction in the basolateral nucleus, and 10-30% enlargement effects in the central and lateral nuclei indicated abnormal structure of the amygdala (corrected p=0.05 on the right; and symmetrical pattern on the left). Psychopathy features specific morphology of the main cerebral structures involved in cognitive and emotional processing, consistent with clinical and functional data, and with a hypothesis of an alternative evolutionary brain development.
Keywords AdultAmphetamine/pharmacologyAmygdala/drug effects/pathologyAntisocial Personality Disorder/pathologyBrain MappingCase-Control StudiesCerebral Cortex/drug effects/pathologyFemaleFunctional LateralityHumansImaging, Three-DimensionalLinear ModelsMagnetic Resonance ImagingMaleMiddle AgedSubstance-Related Disorders/pathology
PMID: 21676597
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BOCCARDI, Marina et al. Cortex and amygdala morphology in psychopathy. In: Psychiatry Research, 2011, vol. 193, n° 2, p. 85-92. doi: 10.1016/j.pscychresns.2010.12.013

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Deposited on : 2019-02-08

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