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Title

The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study

Authors
Pennanen, Corina
Testa, Cristina
Laakso, Mikko P
Hallikainen, Merja
Helkala, Eeva-Liisa
Hänninen, Tuomo
Kivipelto, Miia
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Published in Dementia and Geriatric Cognitive Disorders. 2006, vol. 22, no. 1, p. 60-66
Abstract We investigated the effect of apolipoprotein E (ApoE) on the whole brain in 51 individuals with mild cognitive impairment using voxel-based morphometry. Between cases heterozygous for the ApoE epsilon4 (n = 15) and those who were ApoE epsilon4 noncarriers (n = 28), only the right parahippocampal gyrus, with the entorhinal cortex included, reached the level of statistical significance. In cases homozygous for the epsilon4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus.
Keywords AgedAllelesApolipoprotein E4Apolipoproteins/geneticsApolipoproteins E/geneticsAtrophyBrain/pathologyCognition Disorders/genetics/pathologyCohort StudiesFemaleGenotypeHeterozygoteHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeuropsychological TestsPolymorphism, Genetic/genetics
Identifiers
PMID: 16682795
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PENNANEN, Corina et al. The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study. In: Dementia and Geriatric Cognitive Disorders, 2006, vol. 22, n° 1, p. 60-66. https://archive-ouverte.unige.ch/unige:114075

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Deposited on : 2019-02-08

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