en
Scientific article
English

The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study

Published inDementia and Geriatric Cognitive Disorders, vol. 22, no. 1, p. 60-66
Publication date2006
Abstract

We investigated the effect of apolipoprotein E (ApoE) on the whole brain in 51 individuals with mild cognitive impairment using voxel-based morphometry. Between cases heterozygous for the ApoE epsilon4 (n = 15) and those who were ApoE epsilon4 noncarriers (n = 28), only the right parahippocampal gyrus, with the entorhinal cortex included, reached the level of statistical significance. In cases homozygous for the epsilon4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus.

Keywords
  • Aged
  • Alleles
  • Apolipoprotein E4
  • Apolipoproteins/genetics
  • Apolipoproteins E/genetics
  • Atrophy
  • Brain/pathology
  • Cognition Disorders/genetics/pathology
  • Cohort Studies
  • Female
  • Genotype
  • Heterozygote
  • Humans
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Neuropsychological Tests
  • Polymorphism, Genetic/genetics
Affiliation Not a UNIGE publication
Citation (ISO format)
PENNANEN, Corina et al. The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study. In: Dementia and Geriatric Cognitive Disorders, 2006, vol. 22, n° 1, p. 60–66. doi: 10.1159/000093263
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1420-8008
369views
0downloads

Technical informations

Creation01/04/2019 5:51:00 PM
First validation01/04/2019 5:51:00 PM
Update time03/15/2023 3:43:36 PM
Status update03/15/2023 3:43:35 PM
Last indexation01/17/2024 4:52:14 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack