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Title

HOXA1 A218G polymorphism is associated with smaller cerebellar volume in healthy humans

Authors
Canu, Elisa
Ghidoni, Roberta
Benussi, Luisa
Duchesne, Simon
Testa, Cristina
Binetti, Giuliano
Published in Journal of Neuroimaging. 2009, vol. 19, no. 4, p. 353-358
Abstract The Homeobox A1 (HOXA1) gene plays a critical role during development of the hindbrain in mice. Little is currently known about the relation between this gene and human brain development. The HOXA1 A218G polymorphism has been found to be associated with autism and larger head circumference in autistic patients. Similar effects were revealed also in healthy children but not in adult controls. The aim of this study was to investigate the role of the A218G polymorphism on the hindbrain structure of healthy adults.
Keywords Cerebellum/anatomy & histologyCross-Sectional StudiesFemaleFunctional LateralityGene FrequencyHeterozygoteHomeodomain Proteins/geneticsHumansImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedNerve Fibers, UnmyelinatedOrgan SizePolymorphism, Single NucleotideSequence Analysis, DNATranscription Factors/genetics
Identifiers
PMID: 19018953
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CANU, Elisa et al. HOXA1 A218G polymorphism is associated with smaller cerebellar volume in healthy humans. In: Journal of Neuroimaging, 2009, vol. 19, n° 4, p. 353-358. doi: 10.1111/j.1552-6569.2008.00326.x https://archive-ouverte.unige.ch/unige:114068

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Deposited on : 2019-02-08

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