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HOXA1 A218G polymorphism is associated with smaller cerebellar volume in healthy humans

ContributorsCanu, Elisa; Boccardi, Marina; Ghidoni, Roberta; Benussi, Luisa; Duchesne, Simon; Testa, Cristina; Binetti, Giuliano; Frisoni, Giovanni
Published inJournal of Neuroimaging, vol. 19, no. 4, p. 353-358
Publication date2009
Abstract

The Homeobox A1 (HOXA1) gene plays a critical role during development of the hindbrain in mice. Little is currently known about the relation between this gene and human brain development. The HOXA1 A218G polymorphism has been found to be associated with autism and larger head circumference in autistic patients. Similar effects were revealed also in healthy children but not in adult controls. The aim of this study was to investigate the role of the A218G polymorphism on the hindbrain structure of healthy adults.

Keywords
  • Cerebellum/anatomy & histology
  • Cross-Sectional Studies
  • Female
  • Functional Laterality
  • Gene Frequency
  • Heterozygote
  • Homeodomain Proteins/genetics
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nerve Fibers, Unmyelinated
  • Organ Size
  • Polymorphism, Single Nucleotide
  • Sequence Analysis, DNA
  • Transcription Factors/genetics
Affiliation entities Not a UNIGE publication
Citation (ISO format)
CANU, Elisa et al. HOXA1 A218G polymorphism is associated with smaller cerebellar volume in healthy humans. In: Journal of Neuroimaging, 2009, vol. 19, n° 4, p. 353–358. doi: 10.1111/j.1552-6569.2008.00326.x
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1051-2284
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