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Scientific article
English

Clinical and medial temporal features in a family with mood disorders

Published inNeuroscience Letters, vol. 468, no. 2, p. 93-97
Publication date2010
Abstract

It is debated whether non-affected relatives of patients with affective disorders share a specific brain structure endophenotype. Aim of this work is to explore the medial temporal morphology in affected and non-affected members of a family with mood disorders. Hippocampi and amygdalae were manually traced from the 3D magnetic resonance imaging of five affected family members, 10 non-affected relatives, and 15 unrelated matched controls. Affected and non-affected relatives were characterized by larger left amygdalae (18%, p=0.030), smaller right hippocampus (up to 18%, p<0.0005), and reduced hippocampal asymmetry (p<0.001) than controls. Abnormal, albeit non significant, positive correlations of MTL volumes with age were observed, with the exception of smaller volume of the left hippocampus with advancing age (r=-0.76) in the affected relatives. These data add to the evidence that abnormal medial temporal structures may constitute an endophenotype for affective disorders.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Amygdala/pathology
  • Bipolar Disorder/genetics/pathology
  • Depressive Disorder/genetics/pathology
  • Depressive Disorder, Major/genetics/pathology
  • Female
  • Hippocampus/pathology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Pedigree
  • Temporal Lobe/pathology
Affiliation Not a UNIGE publication
Citation (ISO format)
BOCCARDI, Marina et al. Clinical and medial temporal features in a family with mood disorders. In: Neuroscience Letters, 2010, vol. 468, n° 2, p. 93–97. doi: 10.1016/j.neulet.2009.10.067
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ISSN of the journal0304-3940
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