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Atypical nucleus accumbens morphology in psychopathy: another limbic piece in the puzzle

Bocchetta, Martina
Aronen, Hannu J
Repo-Tiihonen, Eila
Vaurio, Olli
Thompson, Paul M
Tiihonen, Jari
Published in International Journal of Law and Psychiatry. 2013, vol. 36, no. 2, p. 157-167
Abstract Psychopathy has been associated with increased putamen and striatum volumes. The nucleus accumbens - a key structure in reversal learning, less effective in psychopathy - has not yet received specific attention. Moreover, basal ganglia morphology has never been explored. We examined the morphology of the caudate, putamen and accumbens, manually segmented from magnetic resonance images of 26 offenders (age: 32.5 ± 8.4) with medium-high psychopathy (mean PCL-R=30 ± 5) and 25 healthy controls (age: 34.6 ± 10.8). Local differences were statistically modeled using a surface-based radial distance mapping method (p<0.05; multiple comparisons correction through permutation tests). In psychopathy, the caudate and putamen had normal global volume, but different morphology, significant after correction for multiple comparisons, for the right dorsal putamen (permutation test: p=0.02). The volume of the nucleus accumbens was 13% smaller in psychopathy (p corrected for multiple comparisons <0.006). The atypical morphology consisted of predominant anterior hypotrophy bilaterally (10-30%). Caudate and putamen local morphology displayed negative correlation with the lifestyle factor of the PCL-R (permutation test: p=0.05 and 0.03). From these data, psychopathy appears to be associated with an atypical striatal morphology, with highly significant global and local differences of the accumbens. This is consistent with the clinical syndrome and with theories of limbic involvement.
Keywords Alcoholism/diagnosis/pathology/physiopathologyAntisocial Personality Disorder/diagnosis/pathology/physiopathology/psychologyBasal Ganglia/pathology/physiopathologyCaudate Nucleus/pathology/physiopathologyCorpus Striatum/pathology/physiopathologyDominance, Cerebral/physiologyHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalLife StyleLimbic System/pathology/physiopathologyMagnetic Resonance ImagingNucleus Accumbens/pathology/physiopathologyOrgan Size/physiologyPrisoners/legislation & jurisprudence/psychologyPutamen/pathology/physiopathologyStatistics as TopicStreet DrugsSubstance-Related Disorders/diagnosis/pathology/physiopathologyViolence/legislation & jurisprudence/psychology
PMID: 23399314
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BOCCARDI, Marina et al. Atypical nucleus accumbens morphology in psychopathy: another limbic piece in the puzzle. In: International Journal of Law and Psychiatry, 2013, vol. 36, n° 2, p. 157-167. doi: 10.1016/j.ijlp.2013.01.008 https://archive-ouverte.unige.ch/unige:114059

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Deposited on : 2019-02-08

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