Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol

Boccardi, Marina; Ganzola, Rossana; Bocchetta, Martina; Pievani, Michela; Redolfi, Alberto; Bartzokis, George; Camicioli, Richard; Csernansky, John G; de Leon, Mony J; deToledo-Morrell, Leyla; Killiany, Ronald J; Lehéricy, Stéphane; Pantel, Johannes; Pruessner, Jens C; Soininen, H; Watson, Craig; Duchesne, Simon; Jack, Clifford R (Jr); Frisoni, Giovanni

doi:10.3233/JAD-2011-0004

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Title		Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol
Authors		Boccardi, Marina Ganzola, Rossana Bocchetta, Martina Pievani, Michela Redolfi, Alberto Bartzokis, George Camicioli, Richard Csernansky, John G de Leon, Mony J deToledo-Morrell, Leyla Killiany, Ronald J Lehéricy, Stéphane Pantel, Johannes Pruessner, Jens C Soininen, H Watson, Craig Duchesne, Simon Jack, Clifford R (Jr) Frisoni, Giovanni show all authors [1 - 19]
Published in		Journal of Alzheimer's Disease. 2011, vol. 26, no. Suppl 3, p. 61-75
Abstract		Manual segmentation from magnetic resonance imaging (MR) is the gold standard for evaluating hippocampal atrophy in Alzheimer's disease (AD). Nonetheless, different segmentation protocols provide up to 2.5-fold volume differences. Here we surveyed the most frequently used segmentation protocols in the AD literature as a preliminary step for international harmonization. The anatomical landmarks (anteriormost and posteriormost slices, superior, inferior, medial, and lateral borders) were identified from 12 published protocols for hippocampal manual segmentation ([Abbreviation] first author, publication year: [B] Bartzokis, 1998; [C] Convit, 1997; [dTM] deToledo-Morrell, 2004; [H] Haller, 1997; [J] Jack, 1994; [K] Killiany, 1993; [L] Lehericy, 1994; [M] Malykhin, 2007; [Pa] Pantel, 2000; [Pr] Pruessner, 2000; [S] Soininen, 1994; [W] Watson, 1992). The hippocampi of one healthy control and one AD patient taken from the 1.5T MR ADNI database were segmented by a single rater according to each protocol. The accuracy of the protocols' interpretation and translation into practice was checked with lead authors of protocols through individual interactive web conferences. Semantically harmonized landmarks and differences were then extracted, regarding: (a) the posteriormost slice, protocol [B] being the most restrictive, and [H, M, Pa, Pr, S] the most inclusive; (b) inclusion [C, dTM, J, L, M, Pr, W] or exclusion [B, H, K, Pa, S] of alveus/fimbria; (c) separation from the parahippocampal gyrus, [C] being the most restrictive, [B, dTM, H, J, Pa, S] the most inclusive. There were no substantial differences in the definition of the anteriormost slice. This survey will allow us to operationalize differences among protocols into tracing units, measure their impact on the repeatability and diagnostic accuracy of manual hippocampal segmentation, and finally develop a harmonized protocol.
Keywords		Advisory Committees — Algorithms — Alzheimer Disease/pathology — Atrophy — Brain Mapping/standards — Health Surveys — Hippocampus/pathology — Humans — Image Interpretation, Computer-Assisted — Magnetic Resonance Imaging/methods/standards — Reproducibility of Results — Sensitivity and Specificity
Identifiers		DOI: 10.3233/JAD-2011-0004 PMID: 21971451
Full text		Article (Published version) (726 Kb) - Limited access to UNIGE
Citation (ISO format)		BOCCARDI, Marina et al. Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol. In: Journal of Alzheimer's Disease, 2011, vol. 26, n° Suppl 3, p. 61-75. doi: 10.3233/JAD-2011-0004 https://archive-ouverte.unige.ch/unige:114040