Scientific Article
previous document  unige:114040  next document
add to browser collection

Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol

Ganzola, Rossana
Bocchetta, Martina
Pievani, Michela
Redolfi, Alberto
Bartzokis, George
Camicioli, Richard
Csernansky, John G
show hidden authors show all authors [1 - 19]
Published in Journal of Alzheimer's Disease. 2011, vol. 26, no. Suppl 3, p. 61-75
Abstract Manual segmentation from magnetic resonance imaging (MR) is the gold standard for evaluating hippocampal atrophy in Alzheimer's disease (AD). Nonetheless, different segmentation protocols provide up to 2.5-fold volume differences. Here we surveyed the most frequently used segmentation protocols in the AD literature as a preliminary step for international harmonization. The anatomical landmarks (anteriormost and posteriormost slices, superior, inferior, medial, and lateral borders) were identified from 12 published protocols for hippocampal manual segmentation ([Abbreviation] first author, publication year: [B] Bartzokis, 1998; [C] Convit, 1997; [dTM] deToledo-Morrell, 2004; [H] Haller, 1997; [J] Jack, 1994; [K] Killiany, 1993; [L] Lehericy, 1994; [M] Malykhin, 2007; [Pa] Pantel, 2000; [Pr] Pruessner, 2000; [S] Soininen, 1994; [W] Watson, 1992). The hippocampi of one healthy control and one AD patient taken from the 1.5T MR ADNI database were segmented by a single rater according to each protocol. The accuracy of the protocols' interpretation and translation into practice was checked with lead authors of protocols through individual interactive web conferences. Semantically harmonized landmarks and differences were then extracted, regarding: (a) the posteriormost slice, protocol [B] being the most restrictive, and [H, M, Pa, Pr, S] the most inclusive; (b) inclusion [C, dTM, J, L, M, Pr, W] or exclusion [B, H, K, Pa, S] of alveus/fimbria; (c) separation from the parahippocampal gyrus, [C] being the most restrictive, [B, dTM, H, J, Pa, S] the most inclusive. There were no substantial differences in the definition of the anteriormost slice. This survey will allow us to operationalize differences among protocols into tracing units, measure their impact on the repeatability and diagnostic accuracy of manual hippocampal segmentation, and finally develop a harmonized protocol.
Keywords Advisory CommitteesAlgorithmsAlzheimer Disease/pathologyAtrophyBrain Mapping/standardsHealth SurveysHippocampus/pathologyHumansImage Interpretation, Computer-AssistedMagnetic Resonance Imaging/methods/standardsReproducibility of ResultsSensitivity and Specificity
PMID: 21971451
Full text
Article (Published version) (726 Kb) - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
BOCCARDI, Marina et al. Survey of protocols for the manual segmentation of the hippocampus: preparatory steps towards a joint EADC-ADNI harmonized protocol. In: Journal of Alzheimer's Disease, 2011, vol. 26, n° Suppl 3, p. 61-75.

18 hits

0 download


Deposited on : 2019-02-08

Export document
Format :
Citation style :