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Lipase-catalyzed Irreversible Transesterification of Secondary Alcohols Using Isopropenyl Acetate

Published inMonatshefte für Chemie, vol. 134, no. 8, p. 1151-1157
Collection
  • Open Access - Licence nationale Springer 
Publication date2003
Abstract

Asymmetric acetylation of a set of secondary alcohols with the innocuous acyl donor isopropenyl acetate catalyzed by a lipase from Pseudomonas cepacia immobilized on ceramic particles (PSL-C) in toluene as organic medium afforded the chiral alcohols and the corresponding acetates in high enantiomeric excess (up to 99%). An effective baseline separation of the enantiomers of both substrate and product was performed in one analysis without derivatization using gas chromatography on a new chiral stationary phase (CSP) Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex).

Citation (ISO format)
GHANEM, Ashraf, SCHURIG, Volker. Lipase-catalyzed Irreversible Transesterification of Secondary Alcohols Using Isopropenyl Acetate. In: Monatshefte für Chemie, 2003, vol. 134, n° 8, p. 1151–1157. doi: 10.1007/s00706-003-0025-1
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ISSN of the journal0026-9247
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