Scientific article

Transfer of exogenous glycosylphos-phatidylinositol (GPI)-linked molecules to plasma membranes

Published inTrends in cell biology, vol. 6, no. 5, p. 163-167
Publication date1996

Purified GPI-linked molecules incorporate spontaneously in vitro into mammalian cell plasma membranes. Recent evidence suggests that the transferred molecules insert stably into the external leaflet of the acceptor cell plasma membrane through their acyl chains and behave subsequently in a way similar to endogenous GPI-linked molecules. Transfer of GPI-linked proteins between cells has also been documented in vivo and may explain the uptake by host cells o f pathogen-derived virulence factors carrying a GPI anchor. In this comment article, Subburaj Ilangumaran, Peter Robinson and Daniel Hoessli review what is known about GPI transfer and discuss the use of GPI transfer for transient cell-surface expression of foreign proteins.

Affiliation Not a UNIGE publication
Citation (ISO format)
ILANGUMARAN, Subburaj, ROBINSON, P. J., HOESSLI, Daniel. Transfer of exogenous glycosylphos-phatidylinositol (GPI)-linked molecules to plasma membranes. In: Trends in cell biology, 1996, vol. 6, n° 5, p. 163–167. doi: 10.1016/0962-8924(96)20012-1
Updates (1)
ISSN of the journal0962-8924

Technical informations

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