Scientific article

BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci

Published inThe Journal of immunology, vol. 179, no. 4, p. 2428-2434
Publication date2007

The BXSB strain of recombinant inbred mice develops a spontaneous pathology that closely resembles the human disease systemic lupus erythematosus. Six non-MHC loci, Yaa, Bxs1-4, and Bxs6, have been linked to the development of aspects of the disease while a further locus, Bxs5, may be a BXSB-derived disease suppressor. Disease development is delayed in a substrain of BXSB, BXSB/MpJScr-long-lived (BXSB/ll). We compared the genetic derivation of BXSB/ll mice to the original strain, BXSB/MpJ, using microsatellite markers and single nucleotide polymorphisms across the genome. These differences were clustered and included two regions known to be important in the disease-susceptibility of these mice, Bxs5 and 6, as well as regions on chromosomes 5, 6, 9, 11, 12, and 13. We compared BXSB/ll to >20 strains including the BXSB parental SB/Le and C57BL/6 strains. This revealed that BXSB/ll is a separate recombinant inbred line derived from SB/Le and C57BL/6, but distinctly different from BXSB, that most likely arose due to residual heterozygosity in the BXSB stock. Despite the continued presence of the powerful disease-susceptibility locus Bxs3, BXSB/ll mice do not develop disease. We propose that the disappearance of the disease phenotype in the BXSB/ll mice is due to the inheritance of one or more suppressor loci in the differentially inherited intervals between the BXSB/ll and BXSB strains.

  • Animals
  • Breeding
  • Chromosomes/*genetics/immunology
  • Genetic Predisposition to Disease
  • Immunity, Innate/*genetics
  • Lupus Erythematosus, Systemic/genetics/immunology
  • Mice
  • Mice, Inbred Strains
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci/*genetics/immunology
  • Recombination, Genetic/immunology
  • Species Specificity
Affiliation Not a UNIGE publication
Citation (ISO format)
HAYWOOD, M. E. et al. BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci. In: The Journal of immunology, 2007, vol. 179, n° 4, p. 2428–2434. doi: 10.4049/jimmunol.179.4.2428
Updates (1)
ISSN of the journal0022-1767

Technical informations

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