UNIGE document Scientific Article
previous document  unige:112638  next document
add to browser collection

[Bioinformatics analysis of antimicrobial resistance genes and prophages colocalized in human gut metagenomes]

Starikova, E V
Prianichnikov, N A
Govorun, V M
Published in Biomeditsinskaya Khimiya. 2017, vol. 63, no. 6, p. 508-512
Abstract The constant increase of antibiotic-resistant strains of bacteria is caused by extensive uses of antibiotics in medicine and animal breeding. It was suggested that the gut microbiota serves as a reservoir for antibiotics resistance genes that can be carried from symbiotic bacteria to pathogenic ones, in particular, as a result of transduction. In the current study, we have searched for antibiotics resistance genes that are located inside prophages in human gut microbiota using PHASTER prophage predicting tool and CARD antibiotics resistance database. After analysing metagenomic assemblies of eight samples of antibiotic treated patients, lsaE, mdfA and cpxR/cpxA genes were identified inside prophages. The abovementioned genes confer resistance to antimicrobial peptides, pleuromutilin, lincomycins, streptogramins and multidrug resistance. Three (0.46%) of 659 putative prophages predicted in metagenomic assemblies contained antibiotics resistance genes in their sequences.
PMID: 29251611
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
Research group Génomique Evolutionnaire Computationnelle (830)
(ISO format)
STARIKOVA, E V et al. [Bioinformatics analysis of antimicrobial resistance genes and prophages colocalized in human gut metagenomes]. In: Biomeditsinskaya Khimiya, 2017, vol. 63, n° 6, p. 508-512. doi: 10.18097/PBMC20176306508 https://archive-ouverte.unige.ch/unige:112638

174 hits

0 download


Deposited on : 2019-01-09

Export document
Format :
Citation style :