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Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment

Ortega-Gomez, Almudena
Salvermoser, Melanie
Rossaint, Jan
Pick, Robert
Brauner, Janine
Lemnitzer, Patricia
Tilgner, Jessica
de Jong, Renske J
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Published in Circulation. 2016, vol. 134, no. 16, p. 1176-1188
Abstract Therapeutic targeting of arterial leukocyte recruitment in the context of atherosclerosis has been disappointing in clinical studies. Reasons for such failures include the lack of knowledge of arterial-specific recruitment patterns. Here we establish the importance of the cathepsin G (CatG) in the context of arterial myeloid cell recruitment.
Keywords AnimalsArteriesAtherosclerosis/drug therapy/etiology/metabolism/pathologyBiomarkersCathepsin G/antagonists & inhibitors/genetics/metabolismCell Adhesion/geneticsChemokine CCL5/genetics/metabolismChemotaxis/genetics/immunologyDisease ModelsAnimalEndotheliumVascular/metabolism/pathologyHumansIntegrins/metabolismLeukocyte RollingMiceMiceKnockoutMicrocirculationMyeloid Cells/immunology/metabolismProtein BindingShear StrengthVenules
PMID: 27660294
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Research group Groupe Christoph Scheiermann (995)
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ORTEGA-GOMEZ, Almudena et al. Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment. In: Circulation, 2016, vol. 134, n° 16, p. 1176-1188. doi: 10.1161/CIRCULATIONAHA.116.024790

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Deposited on : 2018-12-05

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