TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis

Chicheportiche, Yves; Bourdon, P. R.; Xu, H.; Hsu, Y. M.; Scott, Hamish Steele; Hession, C.; Garcia, Irène; Browning, J. L.

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Title		TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis
Authors		Chicheportiche, Yves Bourdon, P. R. Xu, H. Hsu, Y. M. Scott, Hamish Steele Hession, C. Garcia, Irène Browning, J. L.
Published in		Journal of Biological Chemistry. 1997, vol. 272, no. 51, p. 32401-32410
Abstract		The members of the tumor necrosis factor (TNF) family play pivotal roles in the regulation of the immune system. Here we describe a new ligand in this family, designated TWEAK. The mouse and human versions of this protein are unusually conserved with 93% amino acid identity in the receptor binding domain. The protein was efficiently secreted from cells indicating that, like TNF, TWEAK may have the long range effects of a secreted cytokine. TWEAK transcripts were abundant and found in many tissues, suggesting that TWEAK and TRAIL belong to a new group of widely expressed ligands. Like many members of the TNF family, TWEAK was able to induce interleukin-8 synthesis in a number of cell lines. The human adenocarcinoma cell line, HT29, underwent apoptosis in the presence of both TWEAK and interferon-gamma. Thus, TWEAK resembles many other TNF ligands in the capacity to induce cell death; however, the fact that TWEAK-sensitive cells are relatively rare suggests that TWEAK along with lymphotoxins alpha/beta and possibly CD30L trigger death via a weaker, nondeath domain-dependent mechanism.
Keywords		Adenocarcinoma/metabolism/ pathology — Amino Acid Sequence — Animals — Apoptosis — Apoptosis Regulatory Proteins — Base Sequence — Blotting, Northern — Carrier Proteins/genetics/ metabolism/secretion — Chemokines/secretion — Chromosome Mapping — Chromosomes, Human, Pair 17 — DNA, Complementary — Humans — Ligands — Mice — Molecular Sequence Data — Sequence Homology, Amino Acid — Sequence Homology, Nucleic Acid — Signal Transduction — Tumor Cells, Cultured — Tumor Necrosis Factor-alpha/ metabolism — Tumor Necrosis Factors
Identifiers		DOI: 10.1074/jbc.272.51.32401 PMID: 9405449
Full text		Article - Limited access to UNIGE Other version: http://www.jbc.org/content/272/51/32401.full.pdf
Citation (ISO format)		CHICHEPORTICHE, Yves et al. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. In: Journal of Biological Chemistry, 1997, vol. 272, n° 51, p. 32401-32410. https://archive-ouverte.unige.ch/unige:11193