

Other version: http://www.jbc.org/content/272/51/32401.full.pdf
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TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis |
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Authors | ||
Published in | The Journal of biological chemistry. 1997, vol. 272, no. 51, p. 32401-32410 | |
Abstract | The members of the tumor necrosis factor (TNF) family play pivotal roles in the regulation of the immune system. Here we describe a new ligand in this family, designated TWEAK. The mouse and human versions of this protein are unusually conserved with 93% amino acid identity in the receptor binding domain. The protein was efficiently secreted from cells indicating that, like TNF, TWEAK may have the long range effects of a secreted cytokine. TWEAK transcripts were abundant and found in many tissues, suggesting that TWEAK and TRAIL belong to a new group of widely expressed ligands. Like many members of the TNF family, TWEAK was able to induce interleukin-8 synthesis in a number of cell lines. The human adenocarcinoma cell line, HT29, underwent apoptosis in the presence of both TWEAK and interferon-gamma. Thus, TWEAK resembles many other TNF ligands in the capacity to induce cell death; however, the fact that TWEAK-sensitive cells are relatively rare suggests that TWEAK along with lymphotoxins alpha/beta and possibly CD30L trigger death via a weaker, nondeath domain-dependent mechanism. | |
Keywords | Adenocarcinoma/metabolism/ pathology — Amino Acid Sequence — Animals — Apoptosis — Apoptosis Regulatory Proteins — Base Sequence — Blotting, Northern — Carrier Proteins/genetics/ metabolism/secretion — Chemokines/secretion — Chromosome Mapping — Chromosomes, Human, Pair 17 — DNA, Complementary — Humans — Ligands — Mice — Molecular Sequence Data — Sequence Homology, Amino Acid — Sequence Homology, Nucleic Acid — Signal Transduction — Tumor Cells, Cultured — Tumor Necrosis Factor-alpha/ metabolism — Tumor Necrosis Factors | |
Identifiers | PMID: 9405449 | |
Full text | ||
Citation (ISO format) | CHICHEPORTICHE, Yves et al. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. In: The Journal of biological chemistry, 1997, vol. 272, n° 51, p. 32401-32410. doi: 10.1074/jbc.272.51.32401 https://archive-ouverte.unige.ch/unige:11193 |