Scientific article

A pathway for disulfide bond formation in vivo

Publication date1993

Protein disulfide bond formation in Escherichia coli requires the periplasmic protein DsbA. We describe here mutations in the gene for a second protein, DsbB, which is also necessary for disulfide bond formation. Evidence suggests that DsbB may act by reoxidizing DsbA, thereby regenerating its ability to donate its disulfide bond to target proteins. We propose that DsbB, an integral membrane protein, may be involved in transducing redox potential across the cytoplasmic membrane.

  • Amino Acid Sequence
  • Bacterial Proteins/ genetics/ metabolism
  • Cysteine/metabolism
  • Cystine/metabolism
  • Disulfides/ metabolism
  • Escherichia coli/ genetics/metabolism
  • Genes, Bacterial
  • Isomerases/ genetics/metabolism
  • Membrane Proteins/ genetics/metabolism
  • Models, Biological
  • Molecular Sequence Data
  • Mutagenesis
  • Oxidoreductases/genetics/ metabolism
  • Protein Disulfide-Isomerases
  • Protein Processing, Post-Translational
Affiliation Not a UNIGE publication
Citation (ISO format)
BARDWELL, J. C. et al. A pathway for disulfide bond formation in vivo. In: Proceedings of the National Academy of Sciences of the United States of America, 1993, vol. 90, n° 3, p. 1038–1042.
Main files (1)
ISSN of the journal0027-8424

Technical informations

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