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Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations

Lautner, Ronald
Insel, Philip S
Skillbäck, Tobias
Olsson, Bob
Landén, Mikael
Herukka, Sanna-Kaisa
Hampel, Harald
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Published in Alzheimer's Research and Therapy. 2017, vol. 9, no. 1, p. 87
Abstract From earlier studies it is known that the APOE ε2/ε3/ε4 polymorphism modulates the concentrations of cerebrospinal fluid (CSF) beta-amyloid1-42 (Aβ42) in patients with cognitive decline due to Alzheimer's disease (AD), as well as in cognitively healthy controls. Here, in a large cohort consisting solely of cognitively healthy individuals, we aimed to evaluate how the effect of APOE on CSF Aβ42 varies by age, to understand the association between APOE and the onset of preclinical AD.
Keywords AdolescentAdultAgedAged80 and overAging/cerebrospinal fluid/geneticsAlzheimer Disease/cerebrospinal fluid/geneticsAmyloid beta-Peptides/cerebrospinal fluidApolipoprotein E4/geneticsBiomarkers/cerebrospinal fluidCohort StudiesFemaleHeterozygoteHumansMaleMiddle AgedPeptide Fragments/cerebrospinal fluidProdromal SymptomsYoung Adult
PMID: 29061195
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Research group Troubles de mémoire et maladie d'Alzeimer (935)
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LAUTNER, Ronald et al. Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations. In: Alzheimer's Research & Therapy, 2017, vol. 9, n° 1, p. 87. doi: 10.1186/s13195-017-0313-3 https://archive-ouverte.unige.ch/unige:111281

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Deposited on : 2018-11-21

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