UNIGE document Scientific Article
previous document  unige:111281  next document
add to browser collection
Title

Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations

Authors
Lautner, Ronald
Insel, Philip S
Skillbäck, Tobias
Olsson, Bob
Landén, Mikael
Herukka, Sanna-Kaisa
Hampel, Harald
show hidden authors show all authors [1 - 14]
Published in Alzheimer's Research and Therapy. 2017, vol. 9, no. 1, p. 87
Abstract From earlier studies it is known that the APOE ε2/ε3/ε4 polymorphism modulates the concentrations of cerebrospinal fluid (CSF) beta-amyloid1-42 (Aβ42) in patients with cognitive decline due to Alzheimer's disease (AD), as well as in cognitively healthy controls. Here, in a large cohort consisting solely of cognitively healthy individuals, we aimed to evaluate how the effect of APOE on CSF Aβ42 varies by age, to understand the association between APOE and the onset of preclinical AD.
Keywords AdolescentAdultAgedAged80 and overAging/cerebrospinal fluid/geneticsAlzheimer Disease/cerebrospinal fluid/geneticsAmyloid beta-Peptides/cerebrospinal fluidApolipoprotein E4/geneticsBiomarkers/cerebrospinal fluidCohort StudiesFemaleHeterozygoteHumansMaleMiddle AgedPeptide Fragments/cerebrospinal fluidProdromal SymptomsYoung Adult
Identifiers
PMID: 29061195
Full text
Article (Author postprint) (751 Kb) - public document Free access
Structures
Research group Troubles de mémoire et maladie d'Alzeimer (935)
Citation
(ISO format)
LAUTNER, Ronald et al. Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations. In: Alzheimer's Research & Therapy, 2017, vol. 9, n° 1, p. 87. https://archive-ouverte.unige.ch/unige:111281

25 hits

7 downloads

Update

Deposited on : 2018-11-21

Export document
Format :
Citation style :