Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations

Lautner, Ronald; Insel, Philip S; Skillbäck, Tobias; Olsson, Bob; Landén, Mikael; Frisoni, Giovanni; Herukka, Sanna-Kaisa; Hampel, Harald; Wallin, Anders; Minthon, Lennart; Hansson, Oskar; Blennow, Kaj; Mattsson, Niklas; Zetterberg, Henrik

doi:10.1186/s13195-017-0313-3

Scientific article

English

Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations

ContributorsLautner, Ronald; Insel, Philip S; Skillbäck, Tobias; Olsson, Bob; Landén, Mikael; Frisoni, Giovanni; Herukka, Sanna-Kaisa; Hampel, Harald; Wallin, Anders; Minthon, Lennart; Hansson, Oskar; Blennow, Kaj; Mattsson, Niklas; Zetterberg, Henrik

Published inAlzheimer's Research & Therapy, vol. 9, no. 1, 87

Publication date2017

Abstract

From earlier studies it is known that the APOE ε2/ε3/ε4 polymorphism modulates the concentrations of cerebrospinal fluid (CSF) beta-amyloid1-42 (Aβ42) in patients with cognitive decline due to Alzheimer's disease (AD), as well as in cognitively healthy controls. Here, in a large cohort consisting solely of cognitively healthy individuals, we aimed to evaluate how the effect of APOE on CSF Aβ42 varies by age, to understand the association between APOE and the onset of preclinical AD.

Keywords

Adolescent
Adult
Aged
Aged
80 and over
Aging/cerebrospinal fluid/genetics
Alzheimer Disease/cerebrospinal fluid/genetics
Amyloid beta-Peptides/cerebrospinal fluid
Apolipoprotein E4/genetics
Biomarkers/cerebrospinal fluid
Cohort Studies
Female
Heterozygote
Humans
Male
Middle Aged
Peptide Fragments/cerebrospinal fluid
Prodromal Symptoms
Young Adult

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Research groups

Troubles de mémoire et maladie d'Alzeimer (935)

Citation (ISO format)

LAUTNER, Ronald et al. Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations. In: Alzheimer’s Research & Therapy, 2017, vol. 9, n° 1, p. 87. doi: 10.1186/s13195-017-0313-3

Article (Accepted version)

OA OTHER

Identifiers

PID : unige:111281
DOI : 10.1186/s13195-017-0313-3
PMID : 29061195

Journal ISSN1758-9193

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Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations

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