Scientific article

Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene

Published inScience, vol. 258, no. 5080, p. 302-304
Publication date1992

Approximately half of the neurons produced during embryogenesis normally die before adulthood. Although target-derived neurotrophic factors are known to be major determinants of programmed cell death--apoptosis--the molecular mechanisms by which trophic factors interfere with cell death regulation are largely unknown. Overexpression of the bcl-2 proto-oncogene in cultured sympathetic neurons has now been shown to prevent apoptosis normally induced by deprivation of nerve growth factor. This finding, together with the previous demonstration of bcl-2 expression in the nervous system, suggests that the Bcl-2 protein may be a major mediator of the effects of neurotrophic factors on neuronal survival.

  • Animals
  • Apoptosis/ genetics
  • Cell Death/ genetics
  • Cells, Cultured
  • Ganglia, Sympathetic/cytology
  • Gene Expression
  • Humans
  • Nerve Growth Factors/physiology
  • Neurons/ physiology
  • Proto-Oncogene Proteins/ genetics
  • Proto-Oncogene Proteins c-bcl-2
  • Rats
  • Sympathetic Nervous System/ cytology
  • Transfection
Affiliation Not a UNIGE publication
Citation (ISO format)
GARCIA, Irène et al. Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. In: Science, 1992, vol. 258, n° 5080, p. 302–304.
Updates (1)
ISSN of the journal0036-8075

Technical informations

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