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Titles listALK-positive anaplastic large-cell lymphoma: strong T and B anti-tumour responses may cause hypocellular...
Titles listALK-positive anaplastic large-cell lymphoma: strong T and B anti-tumour responses may cause hypocellular...
Scientific Article
unige:11071 
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ALK-positive anaplastic large-cell lymphoma: strong T and B anti-tumour responses may cause hypocellular aspects of lymph nodes mimicking inflammatory lesions |
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| Authors | ||
| Published in | European Journal of Haematology. 2003, vol. 71, no. 4, p. 243-249 | |
| Abstract | The anaplastic large cell lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma which occurs in children mostly. The ALK protein is highly immunogenic and elicits both humoral and cellular immune responses. A 15-yr-old child presented with fever and adenopathy and did not respond to antibiotics. Biopsy of the enlarged lymph node contained almost no lymphoid element except for a few CD8-positive T cells, plasma cells and isolated CD30-positive blasts. The patient's condition improved following lymphadenectomy but relapse occurred 3 months later with multiple nodes, high fever and an abdominal mass. This time an ALK-positive ALCL was diagnosed and the retrospective analysis of the initial biopsy revealed rare, isolated ALK+ cells. Molecular analysis showed T-cell clones and oligoclonal B cells in both biopsies and peripheral blood of the patient. The tumour cells harbour a t(2;5) translocation, revealing a null phenotype by immunohistochemistry and no evidence for T-cell clonality by Southern blotting. The patient's serum contained anti-ALK antibodies. Our findings suggest that the T-cell clones and anti-ALK antibodies in this patient constitute an anti-tumour response that caused the hypocellularity of the initial lymph node. Hypocellular and oedematous lymph nodes occurring in a child with evocative symptoms should be tested for the presence of ALK. | |
| Keywords | Adolescent — Antigens — CD30/biosynthesis — B-Lymphocytes/ immunology/metabolism — Blotting — Southern — Female — Humans — Immunoblotting — Immunohistochemistry — Inflammation — Lymph Nodes/cytology/pathology — Lymphatic Metastasis — Lymphoma — Large B-Cell — Diffuse/ genetics/ pathology — Non-Hodgkin/genetics — Models — Genetic — RNA — Messenger/metabolism — Retrospective Studies — Reverse Transcriptase Polymerase Chain Reaction — T-Lymphocytes/ immunology — Time Factors — Translocation | |
| Identifiers | PMID: 12950232 | |
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| Citation (ISO format) | BORISCH, Bettina et al. ALK-positive anaplastic large-cell lymphoma: strong T and B anti-tumour responses may cause hypocellular aspects of lymph nodes mimicking inflammatory lesions. In: European Journal of Haematology, 2003, vol. 71, n° 4, p. 243-249. doi: 10.1034/j.1600-0609.2003.00144.x https://archive-ouverte.unige.ch/unige:11071 |
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