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Cardiovascular risk in patients with rheumatoid arthritis

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Published in Seminars in Immunopathology. 2017, vol. 39, no. 4, p. 447-459
Abstract Substantial epidemiologic data have shown an increased risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients. Traditional CV risk factors may partly contribute to CV disease in RA; however, current evidence underlines the important role of inflammation in the pathogenesis of atherosclerosis and amplification of CV risk. Interplays between inflammation and lipid metabolism in the development of atherosclerosis have been established by recent scientific advances. Atherosclerosis is currently viewed as an inflammatory disease, and modifications of lipoproteins during inflammation accelerate atherogenesis. The role of inflammation in the increased CV risk in RA has been further demonstrated by the CV protective effect of methotrexate and TNF antagonists, particularly in patients responding to these treatments. The management of CV risk in RA should include the use of effective disease-modifying anti-rheumatic drugs to control disease activity and the treatment of traditional CV risk factors.
Keywords AnimalsAnti-Inflammatory Agents, Non-Steroidal/adverse effectsArthritis, Rheumatoid/diagnosis/etiology/metabolism/mortalityAutoimmunityCardiovascular Diseases/complications/metabolism/mortality/pathologyComorbidityDisease ManagementExtracellular Traps/genetics/immunology/metabolismGenetic Predisposition to DiseaseHumansLipid MetabolismLipoproteins/metabolismPhenotypeRisk FactorsSeverity of Illness Index
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PMID: 28455580
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Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Mécanisme de l'inflammation articulaire (44)
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LAUPER, Kim, GABAY, Cem. Cardiovascular risk in patients with rheumatoid arthritis. In: Seminars in Immunopathology, 2017, vol. 39, n° 4, p. 447-459. https://archive-ouverte.unige.ch/unige:110680

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Deposited on : 2018-11-12

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