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Regulation and function of interleukin-36 cytokines

Bassoy, Esen Yonca
Towne, Jennifer E
Published in Immunological Reviews. 2018, vol. 281, no. 1, p. 169-178
Abstract The interleukin (IL)-36 cytokines include 3 agonists, IL-36α, IL-36β, and IL-36γ that bind to a common receptor composed of IL-36R and IL-1RAcP to stimulate inflammatory responses. IL-36Ra is a natural antagonist that binds to IL-36R, but does not recruit the co-receptor IL-1RAcP and does not stimulate any intracellular responses. The IL-36 cytokines are expressed predominantly by epithelial cells and act on a number of cells including immune cells, epithelial cells, and fibroblasts. Processing of the N-terminus is required for full agonist or antagonist activity for all IL-36 members. The role of IL-36 has been extensively demonstrated in the skin where it can act on keratinocytes and immune cells to induce a robust inflammatory response that has been implicated in psoriatic disorders. Emerging data also suggest a role for this cytokine family in pulmonary and intestinal physiology and pathology.
Keywords AnimalsArthritis, Psoriatic/immunologyEpithelial Cells/physiologyFibroblasts/physiologyHumansInflammationInterleukin-1/metabolismInterleukin-1 Receptor Accessory Protein/metabolismIntestines/pathology/physiologyProtein BindingReceptors, Interleukin/metabolismSkin/metabolism/pathology
PMID: 29247994
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Research group Mécanisme de l'inflammation articulaire (44)
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BASSOY, Esen Yonca, TOWNE, Jennifer E, GABAY, Cem. Regulation and function of interleukin-36 cytokines. In: Immunological Reviews, 2018, vol. 281, n° 1, p. 169-178. doi: 10.1111/imr.12610 https://archive-ouverte.unige.ch/unige:110678

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Deposited on : 2018-11-12

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