Scientific article
Open access

The parting of the endothelium: miracle, or simply a junctional affair?

Published inJournal of cell science, vol. 113 ( Pt 6), p. 921-933
Publication date2000

Leukocyte extravasation from the blood across the endothelium is vital for the functioning of the immune system. Our understanding of the early steps of this process has developed rapidly. However, it is still unclear how leukocytes undergo the final step, migrating through the junctions that mediate adhesion between adjacent endothelial cells, while preserving the barrier function of the endothelium. The first stage of transmigration - tethering and rolling - is mediated by interactions between selectins on the surface of leukocytes and glycosylated proteins such as GlyCAM-1 on the surface of endothelial cells. Stimulation of the leukocyte by chemokines then induces tight adhesion, which involves binding of activated leukocyte integrins to endothelial ICAM-1/VCAM-1 molecules. Passage of the leukocyte across the endothelium appears to require delocalization of certain endothelial cell molecules and proteolytic degradation of junctional complexes.

  • Animals
  • Capillary Permeability/ physiology
  • Cell Movement/ physiology
  • Endothelium, Vascular/ pathology/ physiology
  • Humans
  • Intercellular Adhesion Molecule-1/physiology
  • Intercellular Junctions/ physiology
  • Leukocytes/ pathology/ physiology
  • Vascular Cell Adhesion Molecule-1/physiology
Affiliation Not a UNIGE publication
Citation (ISO format)
JOHNSON-LEGER, Caroline, AURRAND-LIONS, Michel, IMHOF, Beat. The parting of the endothelium: miracle, or simply a junctional affair? In: Journal of cell science, 2000, vol. 113 ( Pt 6), p. 921–933.
Updates (1)
ISSN of the journal0021-9533

Technical informations

Creation08/27/2010 1:33:27 PM
First validation08/27/2010 1:33:27 PM
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