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Dietary sodium induces a redistribution of the tubular metabolic workload

Maillard, Marc
Bettoni, Carla
Loffing, Johannes
Wagner, Carsten A
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Published in Journal of physiology. 2017, vol. 595, no. 22, p. 6905-6922
Abstract Body Na+ content is tightly controlled by regulated urinary Na+ excretion. The intrarenal mechanisms mediating adaptation to variations in dietary Na+ intake are incompletely characterized. We confirmed and expanded observations in mice that variations in dietary Na+ intake do not alter the glomerular filtration rate but alter the total and cell-surface expression of major Na+ transporters all along the kidney tubule. Low dietary Na+ intake increased Na+ reabsorption in the proximal tubule and decreased it in more distal kidney tubule segments. High dietary Na+ intake decreased Na+ reabsorption in the proximal tubule and increased it in distal segments with lower energetic efficiency. The abundance of apical transporters and Na+ delivery are the main determinants of Na+ reabsorption along the kidney tubule. Tubular O2 consumption and the efficiency of sodium reabsorption are dependent on sodium diet.
Keywords AdaptationPhysiologicalAnimalsGlomerular Filtration RateKidney TubulesProximal/metabolism/physiologyMaleMiceMiceInbred C57BLOxygen/metabolismRenal EliminationRenal ReabsorptionSodiumDietary/metabolism/pharmacokinetics
PMID: 28940314
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Article (Published version) (1.2 MB) - public document Free access
Research group Laboratoire de physiologie et pathophysiologie des cellules rénales (29)
Autre: NCCR Kidney.ch
(ISO format)
UDWAN, Khalil et al. Dietary sodium induces a redistribution of the tubular metabolic workload. In: The Journal of Physiology, 2017, vol. 595, n° 22, p. 6905-6922. doi: 10.1113/JP274927 https://archive-ouverte.unige.ch/unige:109583

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Deposited on : 2018-10-23

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