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Effects of parturition, suckling and pseudopregnancy on variables of disease activity in the B/W mouse model of systemic lupus erythematosus

Publié dansJournal of rheumatology, vol. 20, no. 7, p. 1143-1151
Date de publication1993
Résumé

OBJECTIVE: The pituitary hormone, prolactin, accelerates systemic lupus erythematosus in NZB/NZW F1 (B/W) mice. Our study evaluated disease activity in B/W females experiencing the physiologic hyperprolactinemia of mating, pregnancy, suckling, and pseudopregnancy. METHODS: Nonsuckling postpartum, suckling and pseudopregnant mice were compared to virgin females. Serum prolactin, anti-DNA antibodies (anti-DNA), gp70-anti-gp70 immune complexes, IgM, IgG, albuminuria, and renal function were monitored serially. RESULTS: Females that whelped 2 litters had apparent stimulation of anti-DNA; those that suckled their young had similar premature appearance of anti-DNA as well as delayed, but marked, hypergammaglobulinemia. Pseudopregnant mice, which characteristically secrete repeated surges of prolactin, had significant acceleration of multiple variables of disease activity. CONCLUSIONS: Pregnancy, parturition and suckling did not immediately accelerate lupus in B/W dams, and longevity was not affected in females that had borne litters. Pseudopregnancy was the most effective stimulator of variables of autoimmunity.

Mots-clés
  • Albuminuria/physiopathology
  • Animals
  • Animals, Suckling/ physiology
  • Antibodies, Antinuclear/analysis
  • Antigen-Antibody Complex/analysis
  • Autoimmunity
  • Blood Urea Nitrogen
  • Disease Models, Animal
  • Female
  • Hypergammaglobulinemia/blood/physiopathology
  • Immunoglobulin G/analysis
  • Immunoglobulin M/analysis
  • Kidney/physiology
  • Labor, Obstetric/ physiology
  • Longevity
  • Lupus Erythematosus, Systemic/immunology/ physiopathology
  • Male
  • Mice
  • Mice, Inbred NZB
  • Mice, Inbred Strains
  • Pregnancy
  • Prolactin/blood/physiology
  • Pseudopregnancy/ physiopathology
  • Severity of Illness Index
Structure d'affiliation Pas une publication de l'UNIGE
Citation (format ISO)
MCMURRAY, R. W. et al. Effects of parturition, suckling and pseudopregnancy on variables of disease activity in the B/W mouse model of systemic lupus erythematosus. In: Journal of rheumatology, 1993, vol. 20, n° 7, p. 1143–1151.
Identifiants
ISSN du journal0315-162X
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Création26.08.2010 12:36:37
Première validation26.08.2010 12:36:37
Heure de mise à jour14.03.2023 16:01:37
Changement de statut14.03.2023 16:01:37
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