Scientific article

Effects of parturition, suckling and pseudopregnancy on variables of disease activity in the B/W mouse model of systemic lupus erythematosus

Published inJournal of rheumatology, vol. 20, no. 7, p. 1143-1151
Publication date1993

OBJECTIVE: The pituitary hormone, prolactin, accelerates systemic lupus erythematosus in NZB/NZW F1 (B/W) mice. Our study evaluated disease activity in B/W females experiencing the physiologic hyperprolactinemia of mating, pregnancy, suckling, and pseudopregnancy. METHODS: Nonsuckling postpartum, suckling and pseudopregnant mice were compared to virgin females. Serum prolactin, anti-DNA antibodies (anti-DNA), gp70-anti-gp70 immune complexes, IgM, IgG, albuminuria, and renal function were monitored serially. RESULTS: Females that whelped 2 litters had apparent stimulation of anti-DNA; those that suckled their young had similar premature appearance of anti-DNA as well as delayed, but marked, hypergammaglobulinemia. Pseudopregnant mice, which characteristically secrete repeated surges of prolactin, had significant acceleration of multiple variables of disease activity. CONCLUSIONS: Pregnancy, parturition and suckling did not immediately accelerate lupus in B/W dams, and longevity was not affected in females that had borne litters. Pseudopregnancy was the most effective stimulator of variables of autoimmunity.

  • Albuminuria/physiopathology
  • Animals
  • Animals, Suckling/ physiology
  • Antibodies, Antinuclear/analysis
  • Antigen-Antibody Complex/analysis
  • Autoimmunity
  • Blood Urea Nitrogen
  • Disease Models, Animal
  • Female
  • Hypergammaglobulinemia/blood/physiopathology
  • Immunoglobulin G/analysis
  • Immunoglobulin M/analysis
  • Kidney/physiology
  • Labor, Obstetric/ physiology
  • Longevity
  • Lupus Erythematosus, Systemic/immunology/ physiopathology
  • Male
  • Mice
  • Mice, Inbred NZB
  • Mice, Inbred Strains
  • Pregnancy
  • Prolactin/blood/physiology
  • Pseudopregnancy/ physiopathology
  • Severity of Illness Index
Affiliation Not a UNIGE publication
Citation (ISO format)
MCMURRAY, R. W. et al. Effects of parturition, suckling and pseudopregnancy on variables of disease activity in the B/W mouse model of systemic lupus erythematosus. In: Journal of rheumatology, 1993, vol. 20, n° 7, p. 1143–1151.
ISSN of the journal0315-162X

Technical informations

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