Other version: http://www.springerlink.com/content/x4t5475865740306/
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Scientific Article
unige:10884 
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Actin organization and fibrin-clot retractile activity of cultured mouse fibroblasts |
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| Authors | ||
| Published in | Cell and Tissue Research. 1982, vol. 223, no. 3, p. 665-673 | |
| Abstract | It is known that human and animal fibroblasts are able to induce the retraction of a fibrin clot. In the present study the correlation between (i) fibrin-fibroblasts during growth, (ii) the number of actin stress-lines in mouse fibroblasts during growth in culture, and (iii) the sensitivity of actin stress-lines to a powerful actin-depolymerizing factor (ADF), present in plasma and serum of humans and laboratory animals was investigated. Fibroblasts at early passages (2-4) were tested for these parameters at various intervals after seeding (24, 96, and 168 h). The number of actin stress-lines was progressively higher, while the sensitivity to ADF action was progressively lower in cells cultured from 24 to 168 h; the FCR capacity was significantly decreased at 168 h. These data suggest that cells containing weakly polymerized and/or stabilized actin are more active than those containing highly polymerized and/or stabilized actin in triggering fibroblast contraction. | |
| Keywords | Actin Depolymerizing Factors — Actins/ physiology — Animals — Blood Proteins/physiology — Cells, Cultured — Destrin — Female — Fibrin/ physiology — Fibroblasts/ultrastructure — Mice — Microfilament Proteins — Pregnancy | |
| Identifiers | DOI: 10.1007/bf00218485 PMID: 7094000 | |
| Full text | ||
| Structures | ||
| Citation (ISO format) | CURATOLO, L. et al. Actin organization and fibrin-clot retractile activity of cultured mouse fibroblasts. In: Cell and Tissue Research, 1982, vol. 223, n° 3, p. 665-673. doi: 10.1007/bf00218485 https://archive-ouverte.unige.ch/unige:10884 |
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