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Homonuclear decoupling in the 13C indirect dimension of HSQC experiments for 13C-enriched compounds

Published in Magnetic Resonance in Chemistry. 2018, vol. 56, no. 10, p. 1021-1028
Abstract The two most compelling methods for broadband homonuclear decoupling currently available, Zangger–Sterk (ZS) and pure shift yielded by chirp excitation (PSYCHE), were successfully adapted and tested on the 13C isotope. When applied during the indirect carbon evolution in the HSQC experiment, they both entirely eliminated the extended carbon–carbon multiplet structures observed in this dimension of a non‐decoupled HSQC spectrum of 13C‐enriched cholesterol. The optimized selective pulse modulated using novel non‐equidistant scheme for multisite refocusing (ZS) and the small flip angle saltire chirps (PSYCHE) both proved to be robust and efficient in providing decoupled spectra with a sensitivity of about 25% that of the non‐decoupled HSQC spectra with improved quality compared to earlier results.
Keywords 13C13C‐enriched compoundsBroadband homonuclear decouplingHSQCModulated selective pulsesNMRPSYCHESaltire chirpsZangger–Sterk
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Project FNS: Grant/Award Number: 200021_147069 206021_128746
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BRUCKA, Anna, SHEBERSTOV, Kirill, JEANNERAT, Damien. Homonuclear decoupling in the 13C indirect dimension of HSQC experiments for 13C-enriched compounds. In: Magnetic Resonance in Chemistry, 2018, vol. 56, n° 10, p. 1021-1028. doi: 10.1002/mrc.4697 https://archive-ouverte.unige.ch/unige:107879

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Deposited on : 2018-09-17

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