Scientific article

The Immune System in Pediatric Seizures and Epilepsies

Published inPediatrics, vol. 140, no. 3
Publication date2017

The relation between the immune system and epilepsy has been studied for a long time. Immune activation may precede or follow the appearance of seizures. Depending on the situation, the innate and acquired immunity may be involved to various degrees. The intense, ongoing research has opened encouraging management and therapeutic perspectives for a significant number of patients suffering from seizures. These include the use of various drugs and less conventional approaches with anti-inflammatory or immunomodulatory properties. Data for children remain scarce, however, and the practical implications of recent discoveries in the field remain to be identified formally. The aim of this review is to present current knowledge of the role of immunity in relation to seizures, with a particular emphasis on clinical data available in childhood. More specifically, various autoantibodies involved in autoimmune encephalitis and epilepsy and general pathophysiological hypotheses on the role of immunity in seizure genesis are discussed, specific epilepsy syndromes in which autoimmune components have been studied are summarized, workup recommendations and therapeutic options are suggested, and finally, open questions and future needs are presented.

  • Adaptive Immunity
  • Anti-Inflammatory Agents/therapeutic use
  • Autoantibodies/physiology
  • Child
  • Epilepsy/drug therapy/immunology
  • Humans
  • Immunity
  • Innate
  • Immunologic Factors/therapeutic use
  • Prognosis
  • Seizures/drug therapy/immunology
Citation (ISO format)
KORFF, Christian, DALE, Russell C. The Immune System in Pediatric Seizures and Epilepsies. In: Pediatrics, 2017, vol. 140, n° 3. doi: 10.1542/peds.2016-3534
Main files (1)
Article (Published version)
ISSN of the journal0031-4005

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