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Title

Efficacy and safety of oral sildenafil in children with Down syndrome and pulmonary hypertension

Authors
Rudzinski, Andrzej
Zhang, Min
Published in BMC Cardiovascular Disorders. 2017, vol. 17, no. 1, p. 177
Abstract Despite the increased risk for pulmonary hypertension in children with Down syndrome, the response to treatment with targeted therapies for pulmonary hypertension in these patients is not well characterized. The Sildenafil in Treatment-naive children, Aged 1-17 years, with pulmonary arterial hypertension (STARTS-1) trial was a dose-ranging study of the short-term efficacy and safety of oral sildenafil in children with pulmonary arterial hypertension. We assessed the safety and efficacy of oral sildenafil in children with Down syndrome and pulmonary arterial hypertension.
Keywords AdministrationOralAdolescentAntihypertensive Agents/administration & dosage/adverse effectsArterial Pressure/drug effectsChildChildPreschoolChinaDown Syndrome/complications/diagnosisFemaleHumansHypertensionPulmonary/diagnosis/drug therapy/etiology/physiopathologyInfantMalePulmonary Artery/drug effects/physiopathologySildenafil Citrate/administration & dosage/adverse effectsTime FactorsTreatment OutcomeVascular Resistance/drug effectsVasodilator Agents/administration & dosage/adverse effects
Identifiers
PMID: 28676038
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Article (Published version) (603 Kb) - public document Free access
Structures
Research group L'hypertension pulmonaire (pédiatrie) (228)
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BEGHETTI, Maurice, RUDZINSKI, Andrzej, ZHANG, Min. Efficacy and safety of oral sildenafil in children with Down syndrome and pulmonary hypertension. In: BMC Cardiovascular Disorders, 2017, vol. 17, n° 1, p. 177. https://archive-ouverte.unige.ch/unige:107601

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Deposited on : 2018-09-11

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