Haematological malignancies following temozolomide treatment for paediatric high-grade glioma

Karremann, Michael; Krämer, Nadja; Hoffmann, Marion; Wiese, Maria; Beilken, Andreas; Corbacioglu, Selim; Dilloo, Dagmar; Driever, Pablo Hernáiz; Scheurlen, Wolfram; Kulozik, Andreas; Gielen, Gerrit H; Von Bueren, André; Dürken, Matthias; Kramm, Christof M

doi:10.1016/j.ejca.2017.04.023

Article scientifique

Anglais

Haematological malignancies following temozolomide treatment for paediatric high-grade glioma

Contributeurs/tricesKarremann, Michael; Krämer, Nadja; Hoffmann, Marion; Wiese, Maria; Beilken, Andreas; Corbacioglu, Selim; Dilloo, Dagmar; Driever, Pablo Hernáiz; Scheurlen, Wolfram; Kulozik, Andreas; Gielen, Gerrit H; Von Bueren, André

; Dürken, Matthias; Kramm, Christof M

Publié dansEuropean Journal of Cancer, vol. 81, p. 1-8

Date de publication2017

Résumé

Temozolomide (TMZ) is widely used in high-grade glioma (HGG). There is a major concern of treatment-induced secondary haematological malignancies (SHMs). Due to the poor overall survival of HGG patients, the true incidence is yet elusive. Thus, the aim of this study was to determine the risk of SHMs following TMZ in paediatric HGG.

Mots-clés

Adolescent
Antineoplastic Agents
Alkylating/adverse effects
Austria/epidemiology
Child
Child
Preschool
Dacarbazine/adverse effects/analogs & derivatives
Female
Follow-Up Studies
Germany/epidemiology
Glioma/drug therapy
Hematologic Neoplasms/chemically induced/epidemiology
Humans
Incidence
Infant
Kaplan-Meier Estimate
Male
Switzerland/epidemiology

Structure d'affiliation

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Groupe de recherche

Oncologie et hématologie pédiatrique (907)

Citation (format ISO)

KARREMANN, Michael et al. Haematological malignancies following temozolomide treatment for paediatric high-grade glioma. In: European Journal of Cancer, 2017, vol. 81, p. 1–8. doi: 10.1016/j.ejca.2017.04.023

Article (Published version)

Identifiants

PID : unige:107413
DOI : 10.1016/j.ejca.2017.04.023
PMID : 28586748

ISSN du journal0959-8049

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Création30/08/2018 14:50:00

Première validation30/08/2018 14:50:00

Heure de mise à jour15/03/2023 08:34:37

Changement de statut15/03/2023 08:34:36

Dernière indexation02/05/2024 20:56:25

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Haematological malignancies following temozolomide treatment for paediatric high-grade glioma

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