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Title

White-Fluorescent Dual-Emission Mechanosensitive Membrane Probes that Function by Bending Rather than Twisting
Authors
Humeniuk, Heorhii
Rosspeintner, Arnulf
Licari, Giuseppe Léonardo
Kilin, Vasyl
Bonacina, Luigi
Vauthey, Eric
Sakai, Naomi
Matile, Stefan
Published in Angewandte Chemie: International Edition. 2018, vol. 57, no. 33, p. 10559-10563
Abstract Bent N,N′‐diphenyl‐dihydrodibenzo[a,c]phenazine amphiphiles are introduced as mechanosensitive membrane probes that operate by an unprecedented mechanism, namely, unbending in the excited state as opposed to the previously reported untwisting in the ground and twisting in the excited state. Their dual emission from bent or “closed” and planarized or “open” excited states is shown to discriminate between micelles in water and monomers in solid‐ordered (So), liquid‐disordered (Ld) and bulk membranes. The dual‐emission spectra cover enough of the visible range to produce vesicles that emit white light with ratiometrically encoded information. Strategies to improve the bent mechanophores with expanded π systems and auxochromes are reported, and compatibility with imaging of membrane domains in giant unilamellar vesicles by two‐photon excitation fluorescence (TPEF) microscopy is demonstrated.
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Article (Published version) (2.5 MB) - public document Free access
Other version: http://doi.wiley.com/10.1002/anie.201804662
Structures
Faculté des sciences / Section de chimie et biochimie / Département de chimie physique
Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
Faculté des sciences / Section de physique / Groupe de physique appliquée
Research groups Groupe Matile
Groupe Vauthey
Citation
(ISO format) 		HUMENIUK, Heorhii et al. White-Fluorescent Dual-Emission Mechanosensitive Membrane Probes that Function by Bending Rather than Twisting. In: Angewandte Chemie: International Edition, 2018, vol. 57, n° 33, p. 10559-10563. https://archive-ouverte.unige.ch/unige:107017

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Deposited on : 2018-08-14

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