UNIGE document Scientific Article
previous document  unige:1063  next document
add to browser collection
Title

Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization

Authors
Watanabe, Hideki
Gehrke, Samuel
Tschopp, Jürg
Friedmann, Peter S.
French, Lars E.
Published in Journal of Immunology. 2008, vol. 180, no. 9, p. 5826-32
Abstract Efficient priming of adaptive immunity depends on danger signals provided by innate immune pathways. As an example, inflammasome-mediated activation of caspase-1 and IL-1beta is crucial for the development of reactive T cells targeting sensitizers like dinitrofluorobenzene (DNFB). Surprisingly, DNFB and dinitrothiocyanobenzene provide cross-reactive Ags yet drive opposing, sensitizing vs tolerizing, T cell responses. In this study, we show that, in mice, inflammasome-signaling levels can be modulated to turn dinitrothiocyanobenzene into a sensitizer and DNFB into a tolerizer, and that it correlates with the IL-6 and IL-12 secretion levels, affecting Th1, Th17, and regulatory T cell development. Hence, our data provide the first evidence that the inflammasome can define the type of adaptive immune response elicited by an Ag, and hint at new strategies to modulate T cell responses in vivo.
Keywords AnimalsAntigens/immunologyCaspase 1/immunologyCross Reactions/drug effects/immunologyDinitrobenzenes/pharmacologyDinitrofluorobenzene/pharmacologyHumansImmune Tolerance/drug effects/immunologyImmunity, Innate/drug effects/immunologyInflammation/immunologyInterleukin-1beta/immunologyInterleukin-2/immunologyInterleukin-6/immunologyMiceSignal Transduction/drug effects/immunologyT-Lymphocytes, Regulatory/immunologyTh1 Cells/immunology
Identifiers
PMID: 18424701
Full text
Article (Author postprint) (221 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.jimmunol.org/cgi/content/full/180/9/5826
Structures
Research group Voies d'activation de l'immunité innée au niveau de la peau (156)
Citation
(ISO format)
WATANABE, Hideki et al. Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization. In: Journal of Immunology, 2008, vol. 180, n° 9, p. 5826-32. https://archive-ouverte.unige.ch/unige:1063

187 hits

1 download

Update

Deposited on : 2009-03-04

Export document
Format :
Citation style :