Scientific article
English

Structural plasticity underlies experience-dependent functional plasticity of cortical circuits

Published inThe Journal of neuroscience, vol. 30, no. 14, p. 4927-4932
Publication date2010
Abstract

The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.

Keywords
  • Animals
  • Cerebral Cortex/ physiology/ultrastructure
  • Dendritic Spines/physiology/ultrastructure
  • Learning/ physiology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Nerve Net/ physiology/ultrastructure
  • Neuronal Plasticity/ physiology
  • Synapses/physiology/ultrastructure
  • Vibrissae/ physiology
Citation (ISO format)
WILBRECHT, Linda et al. Structural plasticity underlies experience-dependent functional plasticity of cortical circuits. In: The Journal of neuroscience, 2010, vol. 30, n° 14, p. 4927–4932. doi: 10.1523/JNEUROSCI.6403-09.2010
Main files (1)
Article
accessLevelRestricted
Identifiers
Journal ISSN0270-6474
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