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Scientific article
English

NMDA receptors of the vestibular nuclei neurones

Published inBrain research bulletin, vol. 40, no. 5-6, p. 347-352
Publication date1996
Abstract

Cloning and pharmacological studies have shown that glutamatergic receptors can be divided in two classes (refer to Table 1): ionotropic receptors including N-methyl-D-aspartate (NMDA) and non-NMDA subtypes, and the G-protein-coupled metabotropic receptors (glutamate metabotropic receptor). There are two types of non-NMDA receptors: the AMPA/low-affinity kainate receptor type (the AMPA receptors) activated by a specific agonist, the alpha-amino-3-hydroxy-5-methyl-4-iso-xalone propionate (AMPA), and the high affinity kainate receptors. The vestibular nuclei neurones are endowed with all these types of glutamatergic receptors, which fits well with the fact that various afferents, including the primary vestibular afferents, most probably use glutamate or aspartate as a neurotransmitter. This article is aimed at summarising several past studies of our group and some more recent data obtained in the in vitro whole-brain preparation concerning the NMDA receptors of the central vestibular neurones. In that process, we will detail also many valuable studies of other groups that had been devoted to the same topic.

Keywords
  • Animals
  • Guinea Pigs
  • Neuronal Plasticity/ physiology
  • Receptors, N-Methyl-D-Aspartate/ physiology
  • Vestibular Nuclei/ metabolism
Citation (ISO format)
VIDAL, P. P. et al. NMDA receptors of the vestibular nuclei neurones. In: Brain research bulletin, 1996, vol. 40, n° 5-6, p. 347–352.
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ISSN of the journal0361-9230
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