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Title

MicroRNAs modulate core-clock gene expression in pancreatic islets during early postnatal life in rats

Authors
Jacovetti, Cécile
Rodriguez-Trejo, Adriana
Guay, Claudiane
Sobel, Jonathan
Gattesco, Sonia
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Published in Diabetologia. 2017, vol. 60, no. 10, p. 2011-2020
Abstract Evidence continues to emerge detailing a fine-tuning of the regulation of metabolic processes and energy homeostasis by cell-autonomous circadian clocks. Pancreatic beta cell functional maturation occurs after birth and implies transcriptional changes triggered by a shift in the nutritional supply that occurs at weaning, enabling the adaptation of insulin secretion. So far, the developmental timing and exact mechanisms involved in the initiation of the circadian clock in the growing pancreatic islets have never been addressed.
Keywords Circadian clockMicroRNAsPancreatic isletsPostnatal maturation
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PMID: 28674733
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Article (Published version) (856 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Endocrinologie et horloge circadienne (948)
Project FNS: 31003A-166700
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JACOVETTI, Cécile et al. MicroRNAs modulate core-clock gene expression in pancreatic islets during early postnatal life in rats. In: Diabetologia, 2017, vol. 60, n° 10, p. 2011-2020. https://archive-ouverte.unige.ch/unige:104596

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Deposited on : 2018-05-22

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